PMID- 23301071
OWN - NLM
STAT- MEDLINE
DCOM- 20130820
LR  - 20231104
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 1
DP  - 2013
TI  - Hypothermia protects the brain from transient global ischemia/reperfusion by 
      attenuating endoplasmic reticulum response-induced apoptosis through CHOP.
PG  - e53431
LID - 10.1371/journal.pone.0053431 [doi]
LID - e53431
AB  - Endoplasmic reticulum (ER) stress has been implicated in the pathology of 
      cerebral ischemia. Apoptotic cell death occurs during prolonged period of stress 
      or when the adaptive response fails. Hypothermia blocked the TNF or Fas-mediated 
      extrinsic apoptosis pathway and the mitochondria pathway of apoptosis, however, 
      whether hypothermia can block endoplasmic reticulum mediated apoptosis is never 
      known. This study aimed to elucidate whether hypothermia attenuates brain 
      cerebral ischemia/reperfusion (I/R) damage by suppressing ER stress-induced 
      apoptosis. A 15 min global cerebral ischemia rat model was used in this study. 
      Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) 
      positive cells in hippocampus CA1 were assessed after reperfusion of the brain. 
      The expressions of C/EBP-homologous protein (CHOP) and glucose-regulated protein 
      78 (GRP78) in ischemic hippocampus CA1 were measured at 6, 12, 24 and 48 h after 
      reperfusion. The results showed that hypothermia significantly attenuated brain 
      I/R injury, as shown by reduction in cell apoptosis, CHOP expression, and 
      increase in GRP78 expression. These results suggest that hypothermia could 
      protect brain from I/R injury by suppressing ER stress-induced apoptosis.
FAU - Liu, Xiaojie
AU  - Liu X
AD  - Department of Anesthesiology, Qingdao Municipal Hospital, Shandong, China.
FAU - Wang, Mingshan
AU  - Wang M
FAU - Chen, Huailong
AU  - Chen H
FAU - Guo, Yunliang
AU  - Guo Y
FAU - Ma, Fuguo
AU  - Ma F
FAU - Shi, Fei
AU  - Shi F
FAU - Bi, Yanlin
AU  - Bi Y
FAU - Li, Ying
AU  - Li Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Retracted Publication
DEP - 20130103
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (GRP78 protein, rat)
RN  - 0 (Heat-Shock Proteins)
RN  - 147336-12-7 (Transcription Factor CHOP)
SB  - IM
RIN - PLoS One. 2021 Mar 18;16(3):e0249055. PMID: 33735279
MH  - Animals
MH  - *Apoptosis
MH  - Brain/*metabolism
MH  - Brain Ischemia/metabolism/pathology
MH  - Endoplasmic Reticulum/*metabolism
MH  - Heat-Shock Proteins/metabolism
MH  - Hippocampus/metabolism
MH  - *Hypothermia, Induced
MH  - Immunohistochemistry
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Mitochondria/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Reperfusion Injury/*prevention & control
MH  - Time Factors
MH  - Transcription Factor CHOP/*metabolism
PMC - PMC3536702
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/01/10 06:00
MHDA- 2013/08/21 06:00
PMCR- 2013/01/03
CRDT- 2013/01/10 06:00
PHST- 2012/08/31 00:00 [received]
PHST- 2012/11/28 00:00 [accepted]
PHST- 2013/01/10 06:00 [entrez]
PHST- 2013/01/10 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
PHST- 2013/01/03 00:00 [pmc-release]
AID - PONE-D-12-27607 [pii]
AID - 10.1371/journal.pone.0053431 [doi]
PST - ppublish
SO  - PLoS One. 2013;8(1):e53431. doi: 10.1371/journal.pone.0053431. Epub 2013 Jan 3.