PMID- 23301468
OWN - NLM
STAT- MEDLINE
DCOM- 20130207
LR  - 20130110
IS  - 0255-2930 (Print)
IS  - 0255-2930 (Linking)
VI  - 32
IP  - 12
DP  - 2012 Dec
TI  - [Parkinson's disease combined with depression treated with electroacupuncture and 
      medication and its effect on serum BDNF].
PG  - 1071-4
AB  - OBJECTIVE: To verify the efficacy on Parkinson's disease combined with depression 
      treated with electroacupuncture and medication and to explore the therapeutic 
      mechanism. METHODS: Sixty cases of Parkinson's disease combined with depression 
      were randomized into an acupuncture + medication group and a medication group, 30 
      cases in each one. The conventional therapeutic program of oral administration of 
      madopar and fluoxetine was applied in both groups. In the acupuncture + 
      medication group, on the basic treatment as the above, electroacupuncture was 
      applied to Baihui (GV 20), Yintang (EX-HN 3), Sishencong (EX-HN 1), Taichong (LR 
      3) and Sanyinjiao (SP 6), etc. The level of the serum brain-derived neurotrophic 
      factor (BDNF) and the score of Hamilton depression scale (HAMD) were observed and 
      compared before treatment and after 3 months of treatment. The efficacy was 
      assessed in two groups. RESULTS: The level of BDFN was improved significantly 
      after treatment as compared with that before treatment in two groups (both P < 
      0.05) and the result in the acupuncture + medication group was superior to the 
      medication group (P < 0.05). HAMD scores were reduced significantly after 
      treatment as compared with those before treatment in two groups (both P < 0.05) 
      and the result in the acupuncture + medication group was superior to the 
      medication group (P < 0.05). The total effective rate was 90.0% (27/30) in the 
      acupuncture + medication group, which was better than 83.3% (25/30) in the 
      medication group (P < 0.05). CONCLUSION: The combined therapy of 
      electroacupuncture and medication achieves the significant efficacy on 
      Parkinson's disease combined with depression. This therapy regulates effectively 
      serum BDNF level, relieves depression symptoms of the patients. The efficacy of 
      electroacupuncture combined with medication is superior to the simple medication.
FAU - Xia, Yi
AU  - Xia Y
AD  - Department of TCM, Affiliated Brain Hospital of Nanjing Medical Univerity, 
      Nanjing 210029, Jiangsu Province, China. 88750@sina.com
FAU - Wang, Hai-Dong
AU  - Wang HD
FAU - Ding, Ying
AU  - Ding Y
FAU - Kang, Bing
AU  - Kang B
FAU - Liu, Wei-Guo
AU  - Liu WG
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhen Jiu
JT  - Zhongguo zhen jiu = Chinese acupuncture & moxibustion
JID - 8600658
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Acupuncture Points
MH  - Adult
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depression/blood/*therapy
MH  - *Electroacupuncture
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/blood/*therapy
EDAT- 2013/01/11 06:00
MHDA- 2013/02/08 06:00
CRDT- 2013/01/11 06:00
PHST- 2013/01/11 06:00 [entrez]
PHST- 2013/01/11 06:00 [pubmed]
PHST- 2013/02/08 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhen Jiu. 2012 Dec;32(12):1071-4.