PMID- 23302167
OWN - NLM
STAT- MEDLINE
DCOM- 20140107
LR  - 20130110
IS  - 1673-0860 (Print)
IS  - 1673-0860 (Linking)
VI  - 47
IP  - 10
DP  - 2012 Oct
TI  - [Expressions of key molecules affiliated cytoskeleton in laryngeal squamous cell 
      carcinoma and their implications for prognosis].
PG  - 841-7
AB  - OBJECTIVE: To study the expressions of key assemblies of cytoskeleton, Fascin-1, 
      Ezrin and Paxillin, in laryngeal squamous cell carcinoma (LSCC) and their 
      correlation with clinicopathologic characteristics, cancer recurrence and 
      survival of patients with LSCC. METHODS: The expressions of Fascin-1, Ezrin and 
      Paxillin proteins were detected by immunohistochemistry in 199 cases of LSCC. 
      Unconditional Logistic regression model or Cox proportional hazards model was 
      used for the analyses of recurrent risks and prognostic factors. RESULTS: 
      Significantly increased expression of Fascin-1, Ezrin or Paxillin expression was 
      showed in the LSCC with poorly differentiated, positively cervical lymph nodal 
      metastasis, and clinical stage III + IV respectively (P < 0.05). The expressions 
      of three kinds of proteins in the recurrent cases were higher than those in 
      non-recurrent cases respectively (chi(2) were 42.479, 43.673 and 22.261, P < 0.05). 
      The highest recurrence rate (69.1%) was observed in group of cases with the 
      highly co-expression of the three kinds of proteins (P < 0.05). The expression of 
      Fascin-1 (OR = 7.89, 95%CI 2.26 - 27.53, P = 0.001), or Ezrin (OR = 2.51, 95%CI 
      1.18 - 5.32, P < 0.001) was independent risk for recurrence. Five-year 
      disease-free survival rates of patients with high expression of Fascin-1, Ezrin 
      or Paxillin were lower than those of patients with negative or low expressions 
      for the proteins (P < 0.05). Patients with highly co-expression of three kinds of 
      proteins showed the poorest survival prognosis, with a 5-year disease free 
      survival (DFS) of only 26.4% (P < 0.05), and expressions of three proteins were 
      independent prognostic factors for 5-year DFS (P < 0.05). CONCLUSION: Fascin-1, 
      Ezrin, and Paxillin were correlative with LSCC progression and might be potential 
      predictors for cancer recurrence and survival of patients with LSCC, as well as 
      therapeutic targets for LSCC.
FAU - Gao, Wei
AU  - Gao W
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Shanxi Medical 
      University, Taiyuan, China.
FAU - Wang, Bin-quan
AU  - Wang BQ
FAU - Zhang, Chun-ming
AU  - Zhang CM
FAU - Wen, Shu-xin
AU  - Wen SX
FAU - Chen, Gang-gang
AU  - Chen GG
FAU - Huangfu, Hui
AU  - Huangfu H
FAU - Feng, Yan
AU  - Feng Y
FAU - Zhang, Sen
AU  - Zhang S
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of 
      otorhinolaryngology head and neck surgery
JID - 101247574
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (FSCN1 protein, human)
RN  - 0 (Microfilament Proteins)
RN  - 0 (PXN protein, human)
RN  - 0 (Paxillin)
RN  - 0 (ezrin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/diagnosis/metabolism/*pathology
MH  - Carrier Proteins/*metabolism
MH  - Cytoskeletal Proteins/*metabolism
MH  - Cytoskeleton/metabolism
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/diagnosis/metabolism/*pathology
MH  - Male
MH  - Microfilament Proteins/*metabolism
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Paxillin/*metabolism
MH  - Prognosis
EDAT- 2013/01/11 06:00
MHDA- 2014/01/08 06:00
CRDT- 2013/01/11 06:00
PHST- 2013/01/11 06:00 [entrez]
PHST- 2013/01/11 06:00 [pubmed]
PHST- 2014/01/08 06:00 [medline]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Oct;47(10):841-7.