PMID- 23302250
OWN - NLM
STAT- MEDLINE
DCOM- 20131114
LR  - 20130110
IS  - 0412-4081 (Print)
IS  - 0412-4081 (Linking)
VI  - 48
IP  - 10
DP  - 2012 Oct
TI  - [Current opinions about using of medication intervention as neuroprotective 
      therapy for degenerative ocular fundus diseases].
PG  - 943-7
AB  - Recently, many studies indicated that certain medications can delay the apoptosis 
      of retinal nerve cells at different points during the process of apoptosis and 
      have neuroprotective effect on preventing degenerative ocular fundus diseases. 
      N-methyl-D-aspartate receptor (NMDAR) antagonists, NMDAR-associated calcium 
      channel blockers and acetylcholine receptor agonists have been shown to have 
      neuroprotective effects for retinal damages by inhibiting NMDA-induced 
      excitotoxicity. The inhibitors of nitric oxide synthase (NOS) can prevent the 
      cell apoptosis and reduce the retinal cell loss by suppressing the activity of 
      NOS as well as the production of the nitric oxide. Antioxidants and some Chinese 
      traditional medicine with antioxidant activities can also have protective effect 
      on retinal damage caused by degenerative ocular fundus diseases through their 
      functions in decreasing the peroxidation reaction and the production of the 
      superoxide radicals in the cells. In addition, activation of neurotrophic factor 
      receptors by their ligands plays a key role in neuroprotective and trophic 
      effects for the retina. All of these studies not only provide the foundation, but 
      also offer new theoretical supports for drug neuroprotective therapies in 
      clinical practice.
FAU - Peng, Chun-Xia
AU  - Peng CX
AD  - Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, 
      Beijing, China.
FAU - Li, Gen-Lin
AU  - Li GL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhonghua Yan Ke Za Zhi
JT  - [Zhonghua yan ke za zhi] Chinese journal of ophthalmology
JID - 16210540R
RN  - 0 (Neuroprotective Agents)
SB  - IM
MH  - Animals
MH  - *Fundus Oculi
MH  - Humans
MH  - Neuroprotective Agents/*therapeutic use
MH  - Retinal Degeneration/*drug therapy
EDAT- 2013/01/11 06:00
MHDA- 2013/11/15 06:00
CRDT- 2013/01/11 06:00
PHST- 2013/01/11 06:00 [entrez]
PHST- 2013/01/11 06:00 [pubmed]
PHST- 2013/11/15 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yan Ke Za Zhi. 2012 Oct;48(10):943-7.