PMID- 23302743
OWN - NLM
STAT- MEDLINE
DCOM- 20130819
LR  - 20211021
IS  - 1556-679X (Electronic)
IS  - 1556-6811 (Print)
IS  - 1556-679X (Linking)
VI  - 20
IP  - 3
DP  - 2013 Mar
TI  - Comparative effects of vaccination against porcine circovirus type 2 (PCV2) and 
      porcine reproductive and respiratory syndrome virus (PRRSV) in a PCV2-PRRSV 
      challenge model.
PG  - 369-76
LID - 10.1128/CVI.00497-12 [doi]
AB  - The objective of the present study was to determine the effects of porcine 
      circovirus type 2 (PCV2) and porcine reproductive and respiratory syndrome virus 
      (PRRSV) vaccinations in an experimental PCV2-PRRSV challenge model, based on 
      virological (viremia), immunological (neutralizing antibodies [NAs], gamma 
      interferon-secreting cells [IFN-gamma-SCs], and CD4(+) CD8(+) double-positive cells), 
      and pathological (lesions and antigens in lymph nodes and lungs) evaluations. A 
      total of 72 pigs were randomly divided into 9 groups (8 pigs per group): 5 
      vaccinated and challenged groups, 3 nonvaccinated and challenged groups, and a 
      negative-control group. Vaccination against PCV2 induced immunological responses 
      (NAs and PCV2-specific IFN-gamma-SCs) and reduced PCV2 viremia, PCV2-induced lesions, 
      and PCV2 antigens in the dually infected pigs. However, vaccination against PCV2 
      did not affect the PRRSV immunological responses (NAs and PRRSV-specific 
      IFN-gamma-SCs), PRRSV viremia, PRRSV-induced lesions, or PRRSV antigens in the dually 
      infected pigs. Vaccination against PRRSV did not induce immunological responses 
      (PRRSV-specific IFN-gamma-SCs) or reduce PRRSV viremia, PRRSV-induced lesions, or 
      PRRSV antigens in the dually infected pigs. In addition, vaccination against 
      PRRSV increased PCV2 viremia, PCV2-induced lesions, and PCV2 antigens in the 
      dually infected pigs. In summary, vaccination against PCV2 reduced PCV2 viremia, 
      PCV2-induced lesions, and PCV2 antigens in the dually infected pigs. However, 
      vaccination against PRRSV increased PCV2 viremia, PCV2-induced lesions, and PCV2 
      antigens in the dually infected pigs. Therefore, the PCV2 vaccine decreased the 
      potentiation of PCV2-induced lesions by PRRSV in dually infected pigs. In 
      contrast, the PRRSV vaccine alone did not decrease the potentiation of 
      PCV2-induced lesions by PRRSV in dually infected pigs.
FAU - Park, Changhoon
AU  - Park C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Republic of Korea.
FAU - Oh, Yeonsu
AU  - Oh Y
FAU - Seo, Hwi Won
AU  - Seo HW
FAU - Han, Kiwon
AU  - Han K
FAU - Chae, Chanhee
AU  - Chae C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130109
PL  - United States
TA  - Clin Vaccine Immunol
JT  - Clinical and vaccine immunology : CVI
JID - 101252125
RN  - 0 (Antibodies, Neutralizing)
RN  - 0 (Antibodies, Viral)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD8 Antigens)
RN  - 0 (Viral Vaccines)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Antibodies, Neutralizing
MH  - Antibodies, Viral/blood
MH  - CD4 Antigens/analysis
MH  - CD8 Antigens/analysis
MH  - Circoviridae Infections/immunology/pathology/prevention & control/*veterinary
MH  - Circovirus/*immunology
MH  - Interferon-gamma/metabolism
MH  - Porcine Reproductive and Respiratory Syndrome/immunology/pathology/*prevention & 
      control
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Swine
MH  - T-Lymphocyte Subsets/immunology
MH  - T-Lymphocytes/immunology
MH  - Vaccination/*methods
MH  - Viral Vaccines/administration & dosage/*immunology
MH  - Viremia/immunology/prevention & control
PMC - PMC3592349
EDAT- 2013/01/11 06:00
MHDA- 2013/08/21 06:00
PMCR- 2013/09/01
CRDT- 2013/01/11 06:00
PHST- 2013/01/11 06:00 [entrez]
PHST- 2013/01/11 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - CVI.00497-12 [pii]
AID - 00497-12 [pii]
AID - 10.1128/CVI.00497-12 [doi]
PST - ppublish
SO  - Clin Vaccine Immunol. 2013 Mar;20(3):369-76. doi: 10.1128/CVI.00497-12. Epub 2013 
      Jan 9.