PMID- 23303073
OWN - NLM
STAT- MEDLINE
DCOM- 20140121
LR  - 20211021
IS  - 1740-634X (Electronic)
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 38
IP  - 6
DP  - 2013 May
TI  - Caloric restriction enhances fear extinction learning in mice.
PG  - 930-7
LID - 10.1038/npp.2012.268 [doi]
AB  - Fear extinction learning, the ability to reassess a learned cue of danger as safe 
      when it no longer predicts aversive events, is often dysregulated in anxiety 
      disorders. Selective serotonin reuptake inhibitors (SSRI's) enhance neural 
      plasticity and their ability to enhance fear extinction learning may explain 
      their anxiolytic properties. Caloric restriction (CR) has SSRI-like effects on 
      neural plasticity and anxiety-related behavior. We implemented CR in mice to 
      determine its effects on conditioned-fear responses. Wild type and serotonin 
      transporter (SERT) knockout mice underwent CR for 7 days leading to significant 
      weight loss. Mice were then tested for cued fear learning and anxiety-related 
      behavior. CR markedly enhanced fear extinction learning and its retention in 
      adolescent female mice, and adults of both sexes. These effects of CR were absent 
      in SERT knockout mice. Moreover, CR phenocopied behavioral and molecular effects 
      of chronic fluoxetine, but there was no additive effect of CR in 
      fluoxetine-treated mice. These results demonstrate that CR enhances fear 
      extinction learning through a SERT-dependent mechanism. These results may have 
      implications for eating disorders such as anorexia nervosa (AN), in which there 
      is a high prevalence of anxiety before the onset of dietary restriction and 
      support proposals that in AN, CR is a motivated effort to control dysregulated 
      fear responses and elevated anxiety.
FAU - Riddle, Megan C
AU  - Riddle MC
AD  - Weill Cornell/Rockefeller/Sloan Kettering Tri-Insitutional MD-PhD Program, Weill 
      Cornell Medical College, New York, NY 10065, USA.
FAU - McKenna, Morgan C
AU  - McKenna MC
FAU - Yoon, Yone J
AU  - Yoon YJ
FAU - Pattwell, Siobhan S
AU  - Pattwell SS
FAU - Santos, Patricia Mae G
AU  - Santos PM
FAU - Casey, B J
AU  - Casey BJ
FAU - Glatt, Charles E
AU  - Glatt CE
LA  - eng
GR  - P50 MH062196/MH/NIMH NIH HHS/United States
GR  - P50 MH62196/MH/NIMH NIH HHS/United States
GR  - T32 GM007739/GM/NIGMS NIH HHS/United States
GR  - GM07739/GM/NIGMS NIH HHS/United States
GR  - P50 MH079513/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130103
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
SB  - IM
MH  - Animals
MH  - Caloric Restriction/*methods
MH  - Extinction, Psychological/*physiology
MH  - Fear/*physiology/psychology
MH  - Female
MH  - Learning/*physiology
MH  - Male
MH  - Mice
MH  - Mice, 129 Strain
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Pregnancy
PMC - PMC3629393
EDAT- 2013/01/11 06:00
MHDA- 2014/01/22 06:00
PMCR- 2014/05/01
CRDT- 2013/01/11 06:00
PHST- 2013/01/11 06:00 [entrez]
PHST- 2013/01/11 06:00 [pubmed]
PHST- 2014/01/22 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - npp2012268 [pii]
AID - 10.1038/npp.2012.268 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2013 May;38(6):930-7. doi: 10.1038/npp.2012.268. Epub 
      2013 Jan 3.