PMID- 23303968
OWN - NLM
STAT- MEDLINE
DCOM- 20130701
LR  - 20220408
IS  - 0065-7778 (Print)
IS  - 0065-7778 (Linking)
VI  - 123
DP  - 2012
TI  - Dendritic cells in acute kidney injury: cues from the microenvironment.
PG  - 54-62; discussion 62-3
AB  - Dendritic cells (DCs) and macrophages are critical early initiators of innate 
      immunity in the kidney; they also orchestrate inflammation subsequent to 
      ischemia-reperfusion injury. Hence, these cells hold great promise as targets for 
      pharmacological interventions. Macrophages and DCs are the most abundant 
      leukocytes present in the kidney, and they represent a heterogeneous population 
      of cells that are capable of inducing sterile inflammation after reperfusion, 
      directly through the production of proinflammatory cytokines, chemokines, and 
      other soluble inflammatory mediators, or indirectly through activation of 
      effector T lymphocytes and natural killer T cells. In addition, recent studies 
      have indicated that macrophages participate in tissue repair and DCs possess 
      tolerogenic functions in normal and disease states. Understanding the function of 
      DCs and macrophages as well as the microenvironment that governs their phenotype 
      will shed light on the pathogenesis of kidney disease and offer novel drug 
      targets.
FAU - Okusa, Mark D
AU  - Okusa MD
AD  - University of Virginia Health System, Charlottesville, VA 22908, USA. 
      mdo7y@virginia.edu
FAU - Li, Li
AU  - Li L
LA  - eng
GR  - R01 DK062324/DK/NIDDK NIH HHS/United States
GR  - 5 R01 DK062324/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Trans Am Clin Climatol Assoc
JT  - Transactions of the American Clinical and Climatological Association
JID - 7507559
RN  - 0 (Receptors, Purinergic P1)
SB  - IM
MH  - Acute Kidney Injury/*pathology/physiopathology
MH  - Animals
MH  - Cellular Microenvironment/*physiology
MH  - Dendritic Cells/*pathology
MH  - Disease Models, Animal
MH  - Kidney/*pathology
MH  - Killer Cells, Natural/pathology
MH  - Macrophages/pathology
MH  - Mice
MH  - Phenotype
MH  - Receptors, Purinergic P1/physiology
MH  - Reperfusion Injury/*pathology/physiopathology
MH  - T-Lymphocytes/pathology
PMC - PMC3540592
COIS- Potential Conflicts of Interest: None disclosed.
EDAT- 2013/01/11 06:00
MHDA- 2013/07/03 06:00
PMCR- 2012/01/01
CRDT- 2013/01/11 06:00
PHST- 2013/01/11 06:00 [entrez]
PHST- 2013/01/11 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
PST - ppublish
SO  - Trans Am Clin Climatol Assoc. 2012;123:54-62; discussion 62-3.