PMID- 23311638
OWN - NLM
STAT- MEDLINE
DCOM- 20140715
LR  - 20220311
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 61
IP  - 4
DP  - 2013 Jan 30
TI  - Chemical composition, antioxidative and anti-inflammatory activity of extracts 
      prepared from aerial parts of Oenothera biennis L. and Oenothera paradoxa Hudziok 
      obtained after seeds cultivation.
PG  - 801-10
LID - 10.1021/jf304002h [doi]
AB  - In the present study we investigated the chemical composition of extracts 
      prepared from aerial parts of Oenothera paradoxa Hudziok and Oenothera biennis L. 
      and their antioxidative and anti-inflammatory activities. Ultra high pressure 
      liquid chromatography (UHPLC)-DAD-MS/MS studies showed that both extracts contain 
      a wide variety of polyphenols (39 identified constituents) among which 
      macrocyclic ellagitannin turned out to be the main constituent. During the in 
      vitro studies, using noncellular models, both extracts scavenged reactive oxygen 
      species (ROS) in a concentration-dependent manner, and the lowest SC(50) values 
      were obtained for O(2)(-) and H(2)O(2). Both extracts inhibited ROS production by 
      stimulated human neutrophils. The stronger activity in the case of 
      formyl-met-leu-phenylalanine stimulation suggests that both extracts may act 
      through the receptor-dependent pathway. O. paradoxa extract and O. biennis 
      extract exhibited anti-inflammatory activity by the inhibition of hyaluronidase 
      and lipoxygenase in a concentration-dependent manner. The stronger activity of 
      O.biennis extract toward lipoxygenase may be explained by its higher oenothein B 
      content.
FAU - Granica, Sebastian
AU  - Granica S
AD  - Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of 
      Pharmacy, Medical University of Warsaw, Warsaw, Poland. sgranica@wum.edu.pl
FAU - Czerwinska, Monika E
AU  - Czerwinska ME
FAU - Piwowarski, Jakub P
AU  - Piwowarski JP
FAU - Ziaja, Maria
AU  - Ziaja M
FAU - Kiss, Anna K
AU  - Kiss AK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130122
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Free Radical Scavengers)
RN  - 0 (Hydrolyzable Tannins)
RN  - 0 (Lipoxygenase Inhibitors)
RN  - 0 (Plant Extracts)
RN  - 0 (Polyphenols)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (ellagitannin)
RN  - EC 3.2.1.35 (Hyaluronoglucosaminidase)
SB  - IM
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Antioxidants/*pharmacology
MH  - Free Radical Scavengers/pharmacology
MH  - Humans
MH  - Hyaluronoglucosaminidase/antagonists & inhibitors
MH  - Hydrolyzable Tannins/analysis
MH  - Lipoxygenase Inhibitors/pharmacology
MH  - Neutrophils/metabolism
MH  - Oenothera/*chemistry
MH  - Oenothera biennis/*chemistry
MH  - Plant Components, Aerial/*chemistry
MH  - Plant Extracts/chemistry/*pharmacology
MH  - Polyphenols/analysis
MH  - Reactive Oxygen Species/antagonists & inhibitors
MH  - Species Specificity
EDAT- 2013/01/15 06:00
MHDA- 2014/07/16 06:00
CRDT- 2013/01/15 06:00
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 10.1021/jf304002h [doi]
PST - ppublish
SO  - J Agric Food Chem. 2013 Jan 30;61(4):801-10. doi: 10.1021/jf304002h. Epub 2013 
      Jan 22.