PMID- 23311663
OWN - NLM
STAT- MEDLINE
DCOM- 20130715
LR  - 20130214
IS  - 1475-1313 (Electronic)
IS  - 0275-5408 (Linking)
VI  - 33
IP  - 2
DP  - 2013 Mar
TI  - Comparison of optic area measurement using fundus photography and optical 
      coherence tomography between optic nerve head drusen and control subjects.
PG  - 164-71
LID - 10.1111/opo.12017 [doi]
AB  - PURPOSE: To compare optic disc area measurement between optic nerve head drusen 
      (ONHD) and control subjects using fundus photography, time-domain optical 
      coherence tomography (TD-OCT) and spectral-domain optical coherence tomography 
      (SD-OCT). We also made a comparison between each of the three techniques. 
      METHODS: We performed our study on 66 eyes (66 patients) with ONHD and 70 healthy 
      control subjects (70 controls) with colour ocular fundus photography at 20 masculine 
      (Zeiss FF 450 IR plus), TD-OCT (Stratus OCT) with the Fast Optic Disc protocol 
      and SD-OCT (Cirrus OCT) with the Optic Disc Cube 200 x 200 protocol for 
      measurement of the optic disc area. The measurements were made by two observers 
      and in each measurement a correction of the image magnification factor was 
      performed. Measurement comparison using the Student's t-test/Mann-Whitney U test, 
      the intraclass correlation coefficient, Pearson/Spearman rank correlation 
      coefficient and the Bland-Altman plot was performed in the statistical analysis. 
      RESULTS: Mean and standard deviation (SD) of the optic disc area in ONHD and in 
      controls was 2.38 (0.54) mm(2) and 2.54 (0.42) mm(2), respectively with fundus 
      photography; 2.01 (0.56) mm(2) and 1.66 (0.37) mm(2), respectively with TD-OCT, 
      and 2.03 (0.49) mm(2) and 1.75 (0.38) mm(2), respectively with SD-OCT. In ONHD 
      and controls, repeatability of optic disc area measurement was excellent with 
      fundus photography and optical coherence tomography (TD-OCT and SD-OCT), but with 
      a low degree of agreement between both techniques. CONCLUSIONS: Optic disc area 
      measurement is smaller in ONHD compared to healthy subjects with fundus 
      photography, unlike time-domain and spectral-domain optical coherence tomography 
      in which the reverse is true. Both techniques offer good repeatability, but a low 
      degree of correlation and agreement, which means that optic disc area measurement 
      is not interchangeable or comparable between techniques.
CI  - Ophthalmic & Physiological Optics (c) 2013 The College of Optometrists.
FAU - Flores-Rodriguez, Patricia
AU  - Flores-Rodriguez P
AD  - Alcorcon Foundation University Hospital Ophthalmology Unit, Madrid, Spain. 
      patricia.flores.r@gmail.com
FAU - Gili, Pablo
AU  - Gili P
FAU - Martin-Rios, Maria Dolores
AU  - Martin-Rios MD
FAU - Grifol-Clar, Eulalia
AU  - Grifol-Clar E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130112
PL  - England
TA  - Ophthalmic Physiol Opt
JT  - Ophthalmic & physiological optics : the journal of the British College of 
      Ophthalmic Opticians (Optometrists)
JID - 8208839
SB  - IM
MH  - Adult
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fundus Oculi
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Optic Disk Drusen/*pathology
MH  - Photography/*methods
MH  - Reproducibility of Results
MH  - Tomography, Optical Coherence/*methods
EDAT- 2013/01/15 06:00
MHDA- 2013/07/17 06:00
CRDT- 2013/01/15 06:00
PHST- 2012/08/29 00:00 [received]
PHST- 2012/11/21 00:00 [accepted]
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2013/07/17 06:00 [medline]
AID - 10.1111/opo.12017 [doi]
PST - ppublish
SO  - Ophthalmic Physiol Opt. 2013 Mar;33(2):164-71. doi: 10.1111/opo.12017. Epub 2013 
      Jan 12.