PMID- 23311977
OWN - NLM
STAT- MEDLINE
DCOM- 20131107
LR  - 20220321
IS  - 1502-7708 (Electronic)
IS  - 0036-5521 (Linking)
VI  - 48
IP  - 5
DP  - 2013 May
TI  - Systematic review: symptoms of rebound acid hypersecretion following proton pump 
      inhibitor treatment.
PG  - 515-22
LID - 10.3109/00365521.2012.746395 [doi]
AB  - INTRODUCTION: While the physiological existence of rebound acid hypersecretion 
      (RAHS) after withdrawal of proton pump inhibitors (PPI) therapy is established, 
      the clinical implications are less certain. It has been speculated that a 
      clinical relevant rebound phenomenon may be responsible for difficulties in 
      getting off acid-suppressive medication and partly explain the increase in 
      long-term use of PPI. A number of studies addressing this issue have been 
      published recently. The authors aimed to systematically review the existing 
      evidence of clinically relevant symptoms caused by acid rebound following PPI 
      treatment. MATERIAL AND METHODS: PubMed was searched using the terms "rebound 
      acid hypersecretion" and generic names of PPIs. RESULTS: Five studies were 
      included. Two studies on asymptomatic volunteers found that 44% experienced 
      acid-related symptoms up to 4 weeks after treatment was withdrawn. Symptoms were 
      generally mild to moderate and mainly heartburn and regurgitation. Three studies, 
      using patients with reflux disease, found no signs of symptoms caused by acid 
      rebound. CONCLUSION: Gastric acid rebound hypersecretion following PPI therapy 
      induces reflux-like symptoms post-treatment in asymptomatic volunteers, but the 
      significance of this in patient populations is not clear. The studies in patients 
      with reflux disease found no evidence of symptomatic RAHS, but these studies were 
      hampered by severe methodological weaknesses.
FAU - Lodrup, Anders Bergh
AU  - Lodrup AB
AD  - Department of Medicine, Koge Hospital, Copenhagen University, Koge, Denmark. 
      loedrup.ab@gmail.com
FAU - Reimer, Christina
AU  - Reimer C
FAU - Bytzer, Peter
AU  - Bytzer P
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20130114
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Asymptomatic Diseases
MH  - Gastric Acid/*metabolism
MH  - Gastroesophageal Reflux/*drug therapy/metabolism
MH  - Humans
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Recurrence
EDAT- 2013/01/15 06:00
MHDA- 2013/11/08 06:00
CRDT- 2013/01/15 06:00
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2013/11/08 06:00 [medline]
AID - 10.3109/00365521.2012.746395 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 2013 May;48(5):515-22. doi: 10.3109/00365521.2012.746395. 
      Epub 2013 Jan 14.