PMID- 23312038
OWN - NLM
STAT- MEDLINE
DCOM- 20131021
LR  - 20180924
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 325
IP  - 1-2
DP  - 2013 Feb 15
TI  - Association of Epstein-Barr virus infection with multiple sclerosis in India.
PG  - 86-9
LID - S0022-510X(12)00628-4 [pii]
LID - 10.1016/j.jns.2012.12.004 [doi]
AB  - OBJECTIVES: Epstein-Barr virus (EBV) seroprevalence is high from early childhood 
      in Indian populations, though multiple sclerosis (MS) is uncommon. The present 
      study aims to evaluate the association of EBV infection with MS in Indian 
      patients. METHOD: In this study 140 MS patients and equal number of matched 
      controls were included. Estimation of serum Immunoglobin G (IgG) for EBV Nuclear 
      antigen 1 (EBNA1), viral capsid antigen (EBV-VCA) and early antigen (EB-EA) were 
      obtained by quantitative enzyme linked immunosorbent assay (ELISA). Patients and 
      controls were genotyped for the human leukocyte antigen (HLA) DRB1*1501 allele. 
      RESULTS: A modest difference was observed for EBNA1 (p=0.02) and EBV-VCA (p=0.03) 
      titres in MS patients as compared to healthy controls. There was no association 
      between EBNA1 titres and MS. High EBNA1 titre (>99.75U/l) was significantly 
      associated with HLA DRBI*15:01 (OR=4.92. CI=1.07-22.57) status in MS patients but 
      not in healthy controls (OR=1.19, CI=0.53-2.63). CONCLUSION: Evidence for a 
      strong association with remote EBV infection was lacking in this study of Indian 
      patients with MS. Patients who are carriers of HLA DR15 allele may have high 
      EBNA1 titres. These preliminary results need to be reproduced in an independent 
      and larger dataset.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Pandit, Lekha
AU  - Pandit L
AD  - Center for Advanced Neurological Research, Nitte University, Mangalore, 
      Karnataka, India. panditmng@gmail.com
FAU - Malli, Chaitra
AU  - Malli C
FAU - D'Cunha, Anita
AU  - D'Cunha A
FAU - Shetty, Rajesh
AU  - Shetty R
FAU - Singhal, Bhim
AU  - Singhal B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130109
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Antibodies, Viral)
RN  - 0 (Epstein-Barr Virus Nuclear Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*15:01 antigen)
RN  - O5GA75RST7 (EBV-encoded nuclear antigen 1)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Antibodies, Viral/biosynthesis/blood
MH  - Epstein-Barr Virus Infections/*epidemiology/genetics/*immunology
MH  - Epstein-Barr Virus Nuclear Antigens/blood/immunology
MH  - Female
MH  - HLA-DRB1 Chains/genetics
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*epidemiology/genetics/*immunology
MH  - Seroepidemiologic Studies
EDAT- 2013/01/15 06:00
MHDA- 2013/10/22 06:00
CRDT- 2013/01/15 06:00
PHST- 2012/11/03 00:00 [received]
PHST- 2012/11/30 00:00 [revised]
PHST- 2012/12/05 00:00 [accepted]
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2013/10/22 06:00 [medline]
AID - S0022-510X(12)00628-4 [pii]
AID - 10.1016/j.jns.2012.12.004 [doi]
PST - ppublish
SO  - J Neurol Sci. 2013 Feb 15;325(1-2):86-9. doi: 10.1016/j.jns.2012.12.004. Epub 
      2013 Jan 9.