PMID- 23312069
OWN - NLM
STAT- MEDLINE
DCOM- 20130925
LR  - 20131121
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 110
IP  - 3
DP  - 2013 Aug 28
TI  - Modulatory effect of coffee fruit extract on plasma levels of brain-derived 
      neurotrophic factor in healthy subjects.
PG  - 420-5
LID - 10.1017/S0007114512005338 [doi]
AB  - The present single-dose study was performed to assess the effect of whole coffee 
      fruit concentrate powder (WCFC), green coffee caffeine powder (N677), grape seed 
      extract powder (N31) and green coffee bean extract powder (N625) on blood levels 
      of brain-derived neurotrophic factor (BDNF). Randomly assorted groups of fasted 
      subjects consumed a single, 100mg dose of each material. Plasma samples were 
      collected at time zero (T0) and at 30 min intervals afterwards, up to 120 min. A 
      total of two control groups were included: subjects treated with silica dioxide 
      (as placebo) or with no treatment. The collected data revealed that treatments 
      with N31 and N677 increased levels of plasma BDNF by about 31% under these 
      experimental conditions, whereas treatment with WCFC increased it by 143% (n 10), 
      compared with baseline. These results indicate that WCFC could be used for 
      modulation of BDNF-dependent health conditions. However, larger clinical studies 
      are needed to support this possibility.
FAU - Reyes-Izquierdo, Tania
AU  - Reyes-Izquierdo T
AD  - Applied BioClinical, Inc., 16259 Laguna Canyon Road, Irvine, CA 92618, USA. 
      tania@abclinicaldiscovery.com
FAU - Nemzer, Boris
AU  - Nemzer B
FAU - Shu, Cynthia
AU  - Shu C
FAU - Huynh, Lan
AU  - Huynh L
FAU - Argumedo, Ruby
AU  - Argumedo R
FAU - Keller, Robert
AU  - Keller R
FAU - Pietrzkowski, Zb
AU  - Pietrzkowski Z
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20130114
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Plant Extracts)
RN  - 3G6A5W338E (Caffeine)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Caffeine/pharmacology
MH  - Coffea/*chemistry
MH  - Fruit/*chemistry
MH  - Humans
MH  - Plant Extracts/*pharmacology
MH  - Seeds
MH  - Silicon Dioxide
MH  - Vitis
EDAT- 2013/01/15 06:00
MHDA- 2013/09/26 06:00
CRDT- 2013/01/15 06:00
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2013/09/26 06:00 [medline]
AID - S0007114512005338 [pii]
AID - 10.1017/S0007114512005338 [doi]
PST - ppublish
SO  - Br J Nutr. 2013 Aug 28;110(3):420-5. doi: 10.1017/S0007114512005338. Epub 2013 
      Jan 14.