PMID- 23312788
OWN - NLM
STAT- MEDLINE
DCOM- 20131125
LR  - 20221207
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 27
IP  - 3
DP  - 2013 May-Jun
TI  - Comparison of annual variability in HbA1c and glycated albumin in patients with 
      type 1 vs. type 2 diabetes mellitus.
PG  - 211-3
LID - S1056-8727(12)00338-8 [pii]
LID - 10.1016/j.jdiacomp.2012.12.001 [doi]
AB  - OBJECTIVE: It has been suggested that plasma glucose (PG) levels per se and 
      long-term variations in PG levels are associated with diabetic vascular 
      complications. Glycated albumin (GA) reflects shorter-term glycemic control, as 
      well as postprandial PG levels, as compared to HbA1c. In this study, we 
      hypothesized that GA more strongly reflects long-term variations in PG levels 
      than HbA1c, and compared the variability of HbA1c and that of GA in patients with 
      type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). METHODS: 
      This study included 8 T1DM patients and 48 T2DM patients. Over a 1-year period, 
      HbA1c and GA were measured every month and the mean values and coefficients of 
      variation (CV) for each patient were calculated. RESULTS: In both T1DM and T2DM 
      patients, the CV of GA was significantly higher than the CV of HbA1c. Both the CV 
      of HbA1c and the CV of GA were significantly higher in the T1DM patients than in 
      the T2DM patients. CONCLUSION: The annual variability in GA was greater than that 
      in HbA1c. In addition, the annual variability in HbA1c and that in GA in the T1DM 
      patients were greater than in the T2DM patients. Our findings suggest that GA 
      more accurately reflects long-term variations in PG levels than HbA1c.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Koga, Masafumi
AU  - Koga M
AD  - Department of Internal Medicine, Kawanishi City Hospital, 5-21-1 Higashi-uneno, 
      Kawanishi 666-0195, Japan. m-koga@kawanishi-city-hospital.com
FAU - Murai, Jun
AU  - Murai J
FAU - Morita, Shinya
AU  - Morita S
FAU - Saito, Hiroshi
AU  - Saito H
FAU - Kasayama, Soji
AU  - Kasayama S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
DEP - 20130110
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Serum Albumin)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 0 (Glycated Serum Albumin)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Diabetes Mellitus, Type 1/*blood/complications/therapy
MH  - Diabetes Mellitus, Type 2/*blood/complications/therapy
MH  - Diabetic Angiopathies/epidemiology
MH  - Female
MH  - Glycated Hemoglobin/*analysis
MH  - Glycation End Products, Advanced
MH  - Humans
MH  - Hyperglycemia/*epidemiology/prevention & control
MH  - Japan/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Serum Albumin/*analysis
MH  - Glycated Serum Albumin
EDAT- 2013/01/15 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/01/15 06:00
PHST- 2012/04/17 00:00 [received]
PHST- 2012/11/08 00:00 [revised]
PHST- 2012/12/04 00:00 [accepted]
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S1056-8727(12)00338-8 [pii]
AID - 10.1016/j.jdiacomp.2012.12.001 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2013 May-Jun;27(3):211-3. doi: 
      10.1016/j.jdiacomp.2012.12.001. Epub 2013 Jan 10.