PMID- 23313465
OWN - NLM
STAT- MEDLINE
DCOM- 20140422
LR  - 20161125
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 167
IP  - 5
DP  - 2013 Sep 1
TI  - 18FDG-positron emission tomography (PET) has a role to play in the diagnosis and 
      therapy of infective endocarditis and cardiac device infection.
PG  - 1724-36
LID - S0167-5273(12)01633-6 [pii]
LID - 10.1016/j.ijcard.2012.12.005 [doi]
AB  - In recent years, molecular imaging with positron emission tomography (PET) and 
      more recently, PET coupled with computed tomography (CT) have made a valuable 
      impact in various clinical arenas, primarily within the field of oncology, but 
      also in cardiovascular medicine, particularly in detecting coronary artery 
      disease and myocardial viability. More recently, PET imaging has been proven 
      useful in the diagnosis and evaluation of inflammation and infection at different 
      organ sites. Application of PET in the case of Infective Endocarditis (IE) is 
      still in its infancy and indeed the value of this application in the detection of 
      vegetations is debated primarily due to sensitivity issues of the tracer in 
      cardiac tissue and small vegetations. Interestingly, however, reports are now 
      emerging highlighting the role that this application has played in the diagnosis, 
      assessment of complications such as emboli and metastatic infection and the 
      monitoring of therapeutic treatment of IE. More recently, PET/CT has proven 
      valuable in the diagnosis and assessment of cardiac implantable electronic device 
      (CIED)-related infection and its use has highlighted the contribution that this 
      imaging modality may play in assessing the need for surgery in patients with such 
      infections. This article reviews the literature with regard to the potential 
      value of 2-deoxy-2-[(18)F]fluoro-D-glucose ((18)FDG)-PET, as well as the pitfalls 
      and limitations of this imaging modality, in relation to cardiac infection. The 
      emerging role (18)FDG-PET/CT has in the diagnosis and monitoring of IE, 
      particularly prosthetic valve IE and CIED-related infections should be 
      considered, particularly in difficult cases.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Millar, B Cherie
AU  - Millar BC
AD  - Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast 
      City Hospital, Lisburn Road, Belfast, BT9 7AD, Northern Ireland, UK.
FAU - Prendergast, Bernard D
AU  - Prendergast BD
FAU - Alavi, Abass
AU  - Alavi A
FAU - Moore, John E
AU  - Moore JE
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130111
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Adult
MH  - Endocarditis/*diagnostic imaging/etiology
MH  - Endocarditis, Bacterial/*diagnostic imaging/etiology
MH  - Female
MH  - *Fluorodeoxyglucose F18
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Positron-Emission Tomography/*methods
MH  - Prosthesis-Related Infections/complications/*diagnostic imaging
OTO - NOTNLM
OT  - Cardiac device
OT  - Culture-negative
OT  - Infection
OT  - Infective endocarditis
OT  - Pacemaker
OT  - Positron emission tomography (PET)
EDAT- 2013/01/15 06:00
MHDA- 2014/04/23 06:00
CRDT- 2013/01/15 06:00
PHST- 2012/06/27 00:00 [received]
PHST- 2012/11/19 00:00 [revised]
PHST- 2012/12/01 00:00 [accepted]
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2014/04/23 06:00 [medline]
AID - S0167-5273(12)01633-6 [pii]
AID - 10.1016/j.ijcard.2012.12.005 [doi]
PST - ppublish
SO  - Int J Cardiol. 2013 Sep 1;167(5):1724-36. doi: 10.1016/j.ijcard.2012.12.005. Epub 
      2013 Jan 11.