PMID- 23313958
OWN - NLM
STAT- MEDLINE
DCOM- 20140424
LR  - 20231115
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Print)
IS  - 2047-2404 (Linking)
VI  - 14
IP  - 9
DP  - 2013 Sep
TI  - Low-dose dobutamine adds incremental value to late gadolinium enhancement cardiac 
      magnetic resonance in the prediction of adverse remodelling following acute 
      myocardial infarction.
PG  - 906-13
LID - 10.1093/ehjci/jes320 [doi]
AB  - AIMS: To examine the relative and combined value of late gadolinium enhancement 
      (LGE) and low-dose dobutamine (LDD) cardiac magnetic resonance (CMR) to predict 
      'adverse remodelling' (AR) following acute myocardial infarction (AMI). METHODS 
      AND RESULTS: Forty-five patients with AMI were recruited. CMR was performed 2-4 
      days after presentation and at 6 months. Ventricular wall motion and volume were 
      recorded at rest and following dobutamine infusion. Measures of first pass 
      perfusion, persistent microvascular obstruction (PMO), and LGE were obtained 
      following contrast administration. Quantitation was performed using the MEDIS 6.2 
      software. Regression analysis was employed to determine the univariables and 
      multivariate models most predictive of AR at 6 months. The incremental and 
      relative value of LDD over LGE was investigated. The most predictive univariable 
      was 'volume of PMO' (r = 0.51, r2 = 0.26, P < 0.001). The optimal 'combined' 
      multivariate model, utilizing data from all components, was highly predictive of 
      AR (r = 0.82, r2 = 0.67, P < 0.001). The optimal model using parameters only from 
      the LGE component also predicted remodelling (r = 0.65, r2 = 42.0, P = 0.001) but 
      with less accuracy. In contrast, the optimal model using variables from the LDD 
      component alone predicted remodelling with a similar accuracy to the optimal 
      combined model (r = 0.82, r2 = 0.67, P < 0.001). CONCLUSION: A comprehensive CMR 
      examination accurately predicts AR following AMI. LDD is superior to LGE CMR in 
      this respect. These data suggest that LDD not only adds incremental value to LGE 
      in the prediction of remodelling post-AMI but also may be utilized alone with the 
      same predictive power.
FAU - Scott, Anne E
AU  - Scott AE
AD  - Edinburgh Heart Centre, Little France Crescent, Edinburgh EH164TJ, UK. 
      scousescott@hotmail.com
FAU - Semple, Scott I K
AU  - Semple SI
FAU - Redpath, Thomas W
AU  - Redpath TW
FAU - Hillis, Graham S
AU  - Hillis GS
LA  - eng
GR  - G0701127/MRC_/Medical Research Council/United Kingdom
GR  - MTO12 RGB2140/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130112
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
RN  - 0 (Contrast Media)
RN  - 3S12J47372 (Dobutamine)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Cardiac-Gated Imaging Techniques
MH  - *Contrast Media
MH  - *Dobutamine
MH  - Female
MH  - *Gadolinium DTPA
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*physiopathology
MH  - Predictive Value of Tests
MH  - Ventricular Remodeling/*physiology
PMC - PMC3738097
OTO - NOTNLM
OT  - Adverse remodelling
OT  - Cardiac magnetic resonance
OT  - Late gadolinium enhancement
OT  - Low-dose dobutamine magnetic resonance
OT  - Myocardial infarction
OT  - Viability
EDAT- 2013/01/15 06:00
MHDA- 2014/04/25 06:00
PMCR- 2014/09/01
CRDT- 2013/01/15 06:00
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2014/04/25 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - jes320 [pii]
AID - 10.1093/ehjci/jes320 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2013 Sep;14(9):906-13. doi: 10.1093/ehjci/jes320. 
      Epub 2013 Jan 12.