PMID- 23314658
OWN - NLM
STAT- MEDLINE
DCOM- 20130918
LR  - 20211021
IS  - 1745-7262 (Electronic)
IS  - 1008-682X (Print)
IS  - 1008-682X (Linking)
VI  - 15
IP  - 2
DP  - 2013 Mar
TI  - Brief maternal exposure of rats to the xenobiotics dibutyl phthalate or 
      diethylstilbestrol alters adult-type Leydig cell development in male offspring.
PG  - 261-8
LID - 10.1038/aja.2012.138 [doi]
AB  - Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in 
      the distortion of early male reproductive development, referred to in humans as 
      the testicular dysgenesis syndrome. It is not known, however, whether such early 
      gestational and/or lactational exposure can influence the later adult-type Leydig 
      cell phenotype. In this study, Sprague-Dawley rats were exposed to dibutyl 
      phthalate (DBP; from gestational day (GD) 14.5 to postnatal day (PND) 6) or 
      diethylstilbestrol (DES; from GD14.5 to GD16.5) during a short 
      gestational/lactational window, and male offspring subsequently analysed for 
      various postnatal testicular parameters. All offspring remained in good health 
      throughout the study. Maternal xenobiotic treatment appeared to modify specific 
      Leydig cell gene expression in male offspring, particularly during the dynamic 
      phase of mid-puberty, with serum INSL3 concentrations showing that these 
      compounds led to a faster attainment of peak values, and a modest acceleration of 
      the pubertal trajectory. Part of this effect appeared to be due to a 
      treatment-specific impact on Leydig cell proliferation during puberty for both 
      xenobiotics. Taken together, these results support the notion that maternal 
      exposure to certain xenobiotics can also influence the development of the 
      adult-type Leydig cell population, possibly through an effect on the Leydig stem 
      cell population.
FAU - Ivell, Richard
AU  - Ivell R
AD  - School of Molecular and Biomedical Science, University of Adelaide, Adelaide, 
      Australia.
FAU - Heng, Kee
AU  - Heng K
FAU - Nicholson, Helen
AU  - Nicholson H
FAU - Anand-Ivell, Ravinder
AU  - Anand-Ivell R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130114
PL  - China
TA  - Asian J Androl
JT  - Asian journal of andrology
JID - 100942132
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Insulin)
RN  - 0 (Leydig insulin-like protein)
RN  - 0 (Proteins)
RN  - 0 (Xenobiotics)
RN  - 2286E5R2KE (Dibutyl Phthalate)
RN  - 731DCA35BT (Diethylstilbestrol)
SB  - IM
MH  - Animals
MH  - Dibutyl Phthalate/administration & dosage/*toxicity
MH  - Diethylstilbestrol/administration & dosage/*toxicity
MH  - Endocrine Disruptors/administration & dosage/toxicity
MH  - Female
MH  - Gene Expression Regulation, Developmental/drug effects
MH  - Insulin/genetics/metabolism
MH  - Leydig Cells/*drug effects/metabolism/*pathology
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects
MH  - Proteins/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sexual Maturation
MH  - Testis/drug effects/metabolism/pathology
MH  - Xenobiotics/administration & dosage/toxicity
PMC - PMC3739150
EDAT- 2013/01/15 06:00
MHDA- 2013/09/21 06:00
PMCR- 2013/03/01
CRDT- 2013/01/15 06:00
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2013/09/21 06:00 [medline]
PHST- 2013/03/01 00:00 [pmc-release]
AID - aja2012138 [pii]
AID - 10.1038/aja.2012.138 [doi]
PST - ppublish
SO  - Asian J Androl. 2013 Mar;15(2):261-8. doi: 10.1038/aja.2012.138. Epub 2013 Jan 
      14.