PMID- 23315305 OWN - NLM STAT- MEDLINE DCOM- 20130627 LR - 20210204 IS - 1934-2403 (Electronic) IS - 1530-891X (Linking) VI - 18 Suppl 3 DP - 2012 Nov-Dec TI - Current issues in GLP-1 receptor agonist therapy for type 2 diabetes. PG - 6-26; quiz 27-8 LID - 10.4158/EP12300.RA [doi] AB - The clinical management of hyperglycemia in patients with type 2 diabetes mellitus (T2DM) is guided not only by published treatment algorithms, but also by consideration of recent evidence and through consultation with colleagues and experts. Recent studies have dramatically increased the amount of information regarding the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Topics that may be of particular interest to clinicians who treat T2DM patients include relative glycemic control efficacy of GLP-1 RAs, use of GLP-1 RAs across T2DM progression and in combination with insulin, recent data regarding GLP-1 RA safety, nonglycemic actions of GLP-1 RAs, including weight effects, and impact of GLP-1 RAs on patient quality of life and treatment satisfaction. The following review includes expert consideration of these topics with emphasis on recent, relevant reports to illustrate current perspectives. FAU - Bloomgarden, Zachary T AU - Bloomgarden ZT AD - Department of Medicine, Division of Endocrinology, Diabetes and Bone Disease, Mount Sinai School of Medicine, New York, New York, USA. zbloom@gmail.com FAU - Blonde, Lawrence AU - Blonde L FAU - Garber, Alan J AU - Garber AJ FAU - Wysham, Carol H AU - Wysham CH LA - eng PT - Journal Article PT - Review PL - United States TA - Endocr Pract JT - Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists JID - 9607439 RN - 0 (Hypoglycemic Agents) RN - 89750-14-1 (Glucagon-Like Peptide 1) SB - IM MH - Diabetes Mellitus, Type 2/*drug therapy/*metabolism MH - Glucagon-Like Peptide 1/*agonists MH - Humans MH - Hypoglycemic Agents/therapeutic use EDAT- 2013/01/15 06:00 MHDA- 2013/06/29 06:00 CRDT- 2013/01/15 06:00 PHST- 2013/01/15 06:00 [entrez] PHST- 2013/01/15 06:00 [pubmed] PHST- 2013/06/29 06:00 [medline] AID - S1530-891X(20)43401-9 [pii] AID - 10.4158/EP12300.RA [doi] PST - ppublish SO - Endocr Pract. 2012 Nov-Dec;18 Suppl 3:6-26; quiz 27-8. doi: 10.4158/EP12300.RA.