PMID- 23316192
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130115
LR  - 20230428
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 3
DP  - 2012
TI  - AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV.
PG  - 401
LID - 10.3389/fimmu.2012.00401 [doi]
LID - 401
AB  - As an obligate intracellular parasite, Kaposi sarcoma-associated herpesvirus 
      (KSHV) relies on the host cell machinery to meet its needs for survival, viral 
      replication, production, and dissemination of progeny virions. KSHV is a 
      gammaherpesvirus that is associated with three different malignancies: Kaposi 
      sarcoma (KS), and two B cell lymphoproliferative disorders, primary effusion 
      lymphoma (PEL) and multicentric Castleman's disease. KSHV viral proteins modulate 
      the cellular phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of 
      rapamycin (mTOR) signaling pathway, which is a ubiquitous pathway that also 
      controls B lymphocyte proliferation and development. We review the mechanisms by 
      which KSHV manipulates the PI3K/AKT/mTOR pathway, with a specific focus on B 
      cells.
FAU - Bhatt, Aadra P
AU  - Bhatt AP
AD  - Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel 
      Hill Chapel Hill, NC, USA ; Department of Microbiology and Immunology, University 
      of North Carolina at Chapel Hill Chapel Hill, NC, USA.
FAU - Damania, Blossom
AU  - Damania B
LA  - eng
GR  - P01 CA019014/CA/NCI NIH HHS/United States
GR  - R01 CA096500/CA/NCI NIH HHS/United States
GR  - T32 AI007419/AI/NIAID NIH HHS/United States
GR  - T32 CA071341/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20130107
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3539662
OTO - NOTNLM
OT  - Akt
OT  - B cells
OT  - KSHV
OT  - PI3K
OT  - mTOR
EDAT- 2013/01/15 06:00
MHDA- 2013/01/15 06:01
PMCR- 2012/01/01
CRDT- 2013/01/15 06:00
PHST- 2012/05/02 00:00 [received]
PHST- 2012/12/12 00:00 [accepted]
PHST- 2013/01/15 06:00 [entrez]
PHST- 2013/01/15 06:00 [pubmed]
PHST- 2013/01/15 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2012.00401 [doi]
PST - epublish
SO  - Front Immunol. 2013 Jan 7;3:401. doi: 10.3389/fimmu.2012.00401. eCollection 2012.