PMID- 23317210
OWN - NLM
STAT- MEDLINE
DCOM- 20130702
LR  - 20190606
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 13
IP  - 11
DP  - 2012
TI  - Diagnostic accuracy of ultrasonograph guided fine-needle aspiration cytologic in 
      staging of axillary lymph node metastasis in breast cancer patients: a 
      meta-analysis.
PG  - 5517-23
AB  - PURPOSE: To evaluate the diagnostic accuracy of ultrasonograph and fine-needle 
      aspiration cytologic examination (USG-FNAC) in the staging of axillary lymph node 
      metastasis in breast cancer patients. METHODS: We conducted an electronic search 
      of the literature addressing the performance of USG-FNAC in diagnosis of axillary 
      lymph node metastasis in databases such as Pubmed, Medline, Embase, Ovid and 
      Cochrane library. We introduced a series of diagnostic test indices to evaluate 
      the performance of USG-FNAC by the random effect model (REM), including 
      sensitivity, specificity, likelihood ratios, and diagnostic odds ratios and area 
      under the curve (AUC). RESULTS: A total of 20 studies including 1371 cases and 
      1289 controls were identified. The pooled sensitivity was determined to be 0.66 
      (95% CI 0.64-0.69), specificity 0.98 (95% CI 0.98-0.99), positive likelihood 
      ratio 22.7 (95% CI 15.0-34.49), negative likelihood ratio 0.32 (95% CI 
      0.25-0.41), diagnostic OR 84.2 (95% CI 53.3-133.0). Due to the marginal threshold 
      effect found in some indices of diagnostic validity, we used a summary SROC curve 
      to aggregate data, and obtained a symmetrical curve with an AUC of 0.942. 
      CONCLUSION: The results of this meta-analysis indicated that the USG-FNAC 
      techniques have acceptable diagnostic validity indices and can be used for early 
      staging of axillary lymph node in breast cancer patients.
FAU - Wang, Xi-Wen
AU  - Wang XW
AD  - Bao'an Maternal and Child Health Hospital, Shenzhen, China.
FAU - Xiong, Yun-Hui
AU  - Xiong YH
FAU - Zen, Xiao-Qing
AU  - Zen XQ
FAU - Lin, Hai-Bo
AU  - Lin HB
FAU - Liu, Qing-Yi
AU  - Liu QY
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Axilla
MH  - Biopsy, Fine-Needle
MH  - Breast Neoplasms/*diagnosis
MH  - Case-Control Studies
MH  - *Cytodiagnosis
MH  - Female
MH  - Humans
MH  - Lymphatic Metastasis
MH  - Neoplasm Staging
MH  - Prognosis
MH  - *Ultrasonography, Mammary
EDAT- 2013/01/16 06:00
MHDA- 2013/07/03 06:00
CRDT- 2013/01/16 06:00
PHST- 2013/01/16 06:00 [entrez]
PHST- 2013/01/16 06:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
AID - 10.7314/apjcp.2012.13.11.5517 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2012;13(11):5517-23. doi: 10.7314/apjcp.2012.13.11.5517.