PMID- 23317308
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20220316
IS  - 1600-0765 (Electronic)
IS  - 0022-3484 (Linking)
VI  - 48
IP  - 4
DP  - 2013 Aug
TI  - HLA-DRB and HLA-DQA/HLA-DQB allele and haplotype frequencies in Iranian patients 
      with aggressive periodontitis.
PG  - 533-9
LID - 10.1111/jre.12043 [doi]
AB  - BACKGROUND AND OBJECTIVE: Genetic backgrounds play a key role in susceptibility 
      to and protection against a spectrum of periodontal diseases. Like other 
      infectious diseases, the human leukocyte antigen (HLA) have been found to be 
      associated with periodontitis. This study aimed to investigate differences in 
      allele and haplotype frequencies of HLA class II antigens in a sample of Iranian 
      patients with aggressive periodontitis compared with a healthy control group. 
      MATERIAL AND METHODS: Fifty unrelated patients with aggressive periodontitis and 
      130 healthy volunteers were enrolled in this study. HLA genotyping for HLA-DRB, 
      HLA-DQA1 and HLA-DQB1 was performed using the PCR with sequence-specific primers. 
      Allele and haplotype frequencies were compared across groups. RESULTS: The 
      frequencies of HLA-DQA1*03:01, HLA-DQB1*03:02 and HLA-DQB1*03:05 alleles, as well 
      as that of the HLA-DRB1*04:01 allele, were significantly higher in patients with 
      aggressive periodontitis compared with control subjects (p = 0.01, p = 0.04, p = 
      0.05 and p = 0.04, respectively). In contrast, the frequency of the HLA-DQB1*0603 
      allele was significantly lower in patients with aggressive periodontitis compared 
      with control subjects (p = 0.006; odds ratio = 0.20). With regard to haplotype 
      association, a significantly higher frequency of two haplotypes - 
      HLA-DRB1*04:01/HLA-DQA1*03:01/HLA-DQB1*03:02 and 
      HLA-DRB1*16:01/HLA-DQA1*01:03/HLA-DQB1*05:01 - was observed in patients with 
      aggressive periodontitis compared with healthy controls (p = 0.01, odds ratio = 
      2.56 and p = 0.05, odds ratio = 5.38, respectively). CONCLUSION: These results 
      provide additional evidence that class II HLA polymorphisms, particularly in the 
      DQ locus, are associated with protection against and susceptibility to aggressive 
      periodontitis.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Jazi, M Mousavi
AU  - Jazi MM
AD  - Department of Periodontics, School of Dentistry, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Solgi, G
AU  - Solgi G
FAU - Roosta, H Asl
AU  - Roosta HA
FAU - Noshad, S
AU  - Noshad S
FAU - Moslemi, N
AU  - Moslemi N
FAU - Sadrimanesh, R
AU  - Sadrimanesh R
FAU - Moradi, B
AU  - Moradi B
FAU - Amirzargar, A A
AU  - Amirzargar AA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130114
PL  - United States
TA  - J Periodontal Res
JT  - Journal of periodontal research
JID - 0055107
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DQbeta antigen)
RN  - 0 (HLA-DR beta-Chains)
SB  - IM
MH  - Adult
MH  - Aggressive Periodontitis/genetics/*immunology
MH  - Case-Control Studies
MH  - Dental Plaque Index
MH  - Female
MH  - Gene Frequency/*genetics
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - HLA-DQ alpha-Chains/*genetics
MH  - HLA-DQ beta-Chains/*genetics
MH  - HLA-DR beta-Chains/*genetics
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Iran
MH  - Male
MH  - Periodontal Attachment Loss/genetics/immunology
MH  - Polymorphism, Genetic/genetics
EDAT- 2013/01/16 06:00
MHDA- 2014/02/22 06:00
CRDT- 2013/01/16 06:00
PHST- 2012/11/17 00:00 [accepted]
PHST- 2013/01/16 06:00 [entrez]
PHST- 2013/01/16 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - 10.1111/jre.12043 [doi]
PST - ppublish
SO  - J Periodontal Res. 2013 Aug;48(4):533-9. doi: 10.1111/jre.12043. Epub 2013 Jan 
      14.