PMID- 23317821
OWN - NLM
STAT- MEDLINE
DCOM- 20130916
LR  - 20211203
IS  - 1937-6448 (Print)
IS  - 1937-6448 (Linking)
VI  - 301
DP  - 2013
TI  - Regulation of blood-testis barrier (BTB) dynamics during spermatogenesis via the 
      "Yin" and "Yang" effects of mammalian target of rapamycin complex 1 (mTORC1) and 
      mTORC2.
PG  - 291-358
LID - B978-0-12-407704-1.00006-3 [pii]
LID - 10.1016/B978-0-12-407704-1.00006-3 [doi]
AB  - In mammalian testes, haploid spermatozoa are formed from diploid spermatogonia 
      during spermatogenesis, which is a complicated cellular process. While these 
      cellular events were reported in the 1960s and 1970s, the underlying molecular 
      mechanism(s) that regulates these events remained unexplored until the past 
       approximately 10 years. For instance, adhesion proteins were shown to be integrated components 
      at the Sertoli cell-cell interface and/or the Sertoli-spermatid interface in the 
      late 1980s. But only until recently, studies have demonstrated that some of the 
      adhesion proteins serve as the platform for signal transduction that regulates 
      cell adhesion. In this chapter, a brief summary and critical discussion are 
      provided on the latest findings regarding these cell-adhesion proteins in the 
      testis and their relationship to spermatogenesis. Moreover, antagonistic effects 
      of two mammalian target of rapamycin (mTOR) complexes, known as mTORC1 and 
      mTORC2, on cell-adhesion function in the testis are discussed. Finally, a 
      hypothetic model is presented to depict how these two mTOR-signaling complexes 
      having the "yin" and "yang" antagonistic effects on the Sertoli cell tight 
      junction (TJ)-permeability barrier can maintain the blood-testis barrier (BTB) 
      integrity during the epithelial cycle while preleptotene spermatocytes are 
      crossing the BTB.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Mok, Ka Wai
AU  - Mok KW
AD  - Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for 
      Biomedical Research, Population Council, New York, USA.
FAU - Mruk, Dolores D
AU  - Mruk DD
FAU - Cheng, C Yan
AU  - Cheng CY
LA  - eng
GR  - R01 HD056034/HD/NICHD NIH HHS/United States
GR  - U54 HD029990/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - Netherlands
TA  - Int Rev Cell Mol Biol
JT  - International review of cell and molecular biology
JID - 101475846
RN  - 0 (Actins)
RN  - 0 (Multiprotein Complexes)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 2)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Actins/metabolism
MH  - Animals
MH  - Blood-Testis Barrier/*metabolism
MH  - Humans
MH  - Male
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Mechanistic Target of Rapamycin Complex 2
MH  - Models, Biological
MH  - Multiprotein Complexes/*metabolism
MH  - *Spermatogenesis
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC4086807
MID - NIHMS587940
EDAT- 2013/01/16 06:00
MHDA- 2013/09/17 06:00
PMCR- 2014/07/08
CRDT- 2013/01/16 06:00
PHST- 2013/01/16 06:00 [entrez]
PHST- 2013/01/16 06:00 [pubmed]
PHST- 2013/09/17 06:00 [medline]
PHST- 2014/07/08 00:00 [pmc-release]
AID - B978-0-12-407704-1.00006-3 [pii]
AID - 10.1016/B978-0-12-407704-1.00006-3 [doi]
PST - ppublish
SO  - Int Rev Cell Mol Biol. 2013;301:291-358. doi: 10.1016/B978-0-12-407704-1.00006-3.