PMID- 23318255
OWN - NLM
STAT- MEDLINE
DCOM- 20130801
LR  - 20211021
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1499
DP  - 2013 Mar 7
TI  - Progesterone receptor expression in the brain of the socially monogamous and 
      paternal male prairie vole.
PG  - 12-20
LID - S0006-8993(13)00054-1 [pii]
LID - 10.1016/j.brainres.2013.01.011 [doi]
AB  - Differences in the social organization and behavior of male mammals are 
      attributable to species differences in neurochemistry, including differential 
      expression of steroid hormone receptors. However, the distribution of progestin 
      receptors (PR) in a socially monogamous and spontaneously parental male rodent 
      has never been examined. Here we determined if PR exists and is regulated by 
      testicular hormones in forebrain sites traditionally influencing 
      socioreproductive behaviors in male prairie voles (Microtus ochrogaster). We 
      hypothesized that PR expression in male prairie voles would differ from that 
      described in other male rodents because PR activity inhibits parental behaviors 
      and social memory in laboratory mice and rats. Adult male prairie voles received 
      a sham surgery, were gonadectomized, or were gonadectomized and implanted with a 
      testosterone-filled capsule. PR immunoreactivity (PRir) was measured four weeks 
      later in areas of the hypothalamus and extended amygdala. A group of gonadally 
      intact female prairie voles was included to reveal possible sex differences. We 
      found considerable PRir in all sites examined. Castration reduced PRir in males' 
      medial preoptic nucleus, anteroventral periventricular nucleus, ventromedial 
      hypothalamus, and posterodorsal medial amygdala, and it was maintained in these 
      sites by testosterone. This is the first study to examine PR expression in brain 
      sites involved in socioreproductive behaviors in a socially monogamous and 
      spontaneously paternal male rodent. Our results mostly reveal cross-species 
      conservation in the distribution and hormone sensitivity of PR expression. 
      Because PR interferes with aspects of sociality in other male rodents, PR may 
      eventually be found to have different neurobiological actions in male prairie 
      voles.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Williams, Brittany
AU  - Williams B
AD  - Department of Biological Sciences, 1200N Dupont Hwy, Delaware State University, 
      Dover, DE 19901, USA.
FAU - Northcutt, Katharine V
AU  - Northcutt KV
FAU - Rusanowsky, Rebecca D
AU  - Rusanowsky RD
FAU - Mennella, Thomas A
AU  - Mennella TA
FAU - Lonstein, Joseph S
AU  - Lonstein JS
FAU - Quadros-Mennella, Princy S
AU  - Quadros-Mennella PS
LA  - eng
GR  - 8P20GM103446-11/GM/NIGMS NIH HHS/United States
GR  - P20 GM103446/GM/NIGMS NIH HHS/United States
GR  - P20 GM103653/GM/NIGMS NIH HHS/United States
GR  - P20 RR016472/RR/NCRR NIH HHS/United States
GR  - 5P20RR016472-11/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20130111
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Receptors, Progesterone)
SB  - IM
MH  - Animals
MH  - Arvicolinae/*metabolism
MH  - Brain/*metabolism
MH  - Female
MH  - Male
MH  - Receptors, Progesterone/*biosynthesis
PMC - PMC3570709
MID - NIHMS435523
EDAT- 2013/01/16 06:00
MHDA- 2013/08/02 06:00
PMCR- 2014/03/07
CRDT- 2013/01/16 06:00
PHST- 2012/07/27 00:00 [received]
PHST- 2013/01/04 00:00 [revised]
PHST- 2013/01/05 00:00 [accepted]
PHST- 2013/01/16 06:00 [entrez]
PHST- 2013/01/16 06:00 [pubmed]
PHST- 2013/08/02 06:00 [medline]
PHST- 2014/03/07 00:00 [pmc-release]
AID - S0006-8993(13)00054-1 [pii]
AID - 10.1016/j.brainres.2013.01.011 [doi]
PST - ppublish
SO  - Brain Res. 2013 Mar 7;1499:12-20. doi: 10.1016/j.brainres.2013.01.011. Epub 2013 
      Jan 11.