PMID- 23318518
OWN - NLM
STAT- MEDLINE
DCOM- 20130326
LR  - 20211021
IS  - 2168-6157 (Electronic)
IS  - 2168-6149 (Print)
IS  - 2168-6149 (Linking)
VI  - 70
IP  - 1
DP  - 2013 Jan
TI  - Persistent intrathecal antibody synthesis 15 years after recovering from 
      anti-N-methyl-D-aspartate receptor encephalitis.
PG  - 117-9
LID - 10.1001/jamaneurol.2013.585 [doi]
AB  - BACKGROUND: Anti- N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe 
      autoimmune disorder characterized by high intrathecal antibody synthesis. Little 
      is known about the long-term follow-up of the cerebrospinal fluid antibody 
      status. OBJECTIVE: To describe persistent intrathecal antibody synthesis in a 
      clinically healthy person 15 years after recovering from anti-NMDAR encephalitis. 
      DESIGN: Case report. SETTING: Academic medical center. PATIENT: A 40-year-old 
      woman who had been diagnosed as having encephalitis of unknown origin in 1995. 
      MAIN OUTCOME MEASURES: Clinical evaluation and NMDAR antibody testing. RESULTS: 
      On reexamination in 2011, the patient had fully recovered. Investigation of 
      archived as well as follow-up serum and cerebrospinal fluid samples revealed 
      intrathecal synthesis of NMDAR antibodies. CONCLUSIONS: This is the longest 
      follow-up on a patient with anti-NMDAR encephalitis. Our findings emphasize that 
      intrathecal antibody synthesis does not necessarily reflect disease activity and 
      that the significance of NMDAR antibody titers needs to be interpreted for each 
      patient according to the clinical context.
FAU - Hansen, Hans-Christian
AU  - Hansen HC
AD  - Department of Neurology and Psychiatry, Friedrich-Ebert-Hospital, Neumunster, 
      Germany.
FAU - Klingbeil, Christine
AU  - Klingbeil C
FAU - Dalmau, Josep
AU  - Dalmau J
FAU - Li, Wenhan
AU  - Li W
FAU - Weissbrich, Benedikt
AU  - Weissbrich B
FAU - Wandinger, Klaus-Peter
AU  - Wandinger KP
LA  - eng
GR  - R56 CA089054/CA/NCI NIH HHS/United States
GR  - R01CA89054/CA/NCI NIH HHS/United States
GR  - R01 MH094741/MH/NIMH NIH HHS/United States
GR  - R01NS077851/NS/NINDS NIH HHS/United States
GR  - R01 NS077851/NS/NINDS NIH HHS/United States
GR  - R01 CA107192/CA/NCI NIH HHS/United States
GR  - R01MH094741/MH/NIMH NIH HHS/United States
GR  - R01 CA089054/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - JAMA Neurol
JT  - JAMA neurology
JID - 101589536
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Adult
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/cerebrospinal 
      fluid/*immunology/physiopathology
MH  - Autoantibodies/*biosynthesis/cerebrospinal fluid
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Receptors, N-Methyl-D-Aspartate/*immunology
MH  - Time Factors
PMC - PMC3707142
MID - NIHMS490665
EDAT- 2013/01/16 06:00
MHDA- 2013/03/27 06:00
PMCR- 2013/07/10
CRDT- 2013/01/16 06:00
PHST- 2013/01/16 06:00 [entrez]
PHST- 2013/01/16 06:00 [pubmed]
PHST- 2013/03/27 06:00 [medline]
PHST- 2013/07/10 00:00 [pmc-release]
AID - 1557586 [pii]
AID - 10.1001/jamaneurol.2013.585 [doi]
PST - ppublish
SO  - JAMA Neurol. 2013 Jan;70(1):117-9. doi: 10.1001/jamaneurol.2013.585.