PMID- 23318672
OWN - NLM
STAT- MEDLINE
DCOM- 20130829
LR  - 20130225
IS  - 1872-9754 (Electronic)
IS  - 0197-0186 (Linking)
VI  - 62
IP  - 3
DP  - 2013 Feb
TI  - Serum level of brain-derived neurotrophic factor in fibromyalgia syndrome 
      correlates with depression but not anxiety.
PG  - 281-6
LID - S0197-0186(13)00004-1 [pii]
LID - 10.1016/j.neuint.2013.01.001 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has been known to play a role in 
      fibromyalgia syndrome (FMS) patients. Depression and anxiety are quite common 
      additional symptoms in FMS. However the role of BDNF in these symptoms still 
      needs to be elucidated. Although BDNF has been shown to be relevant in major 
      depression, however studies could not show such differences between FMS patients 
      with and without major depression. As mood-related symptom occurs frequently and 
      differs in its intensity in FMS patients, BDNF level should be measured in 
      subgroup regarding depression and anxiety scale. Therefore the aim of this study 
      was to evaluate the correlation of BDNF in serum of FMS with intensity of 
      depression and anxiety. Additionally, interleukin (IL)-6 was measured. This study 
      showed that serum level of BDNF was age-dependent in HCs. FMS patients had higher 
      level of serum BDNF as compared to HC. Additionally, serum level of BDNF showed 
      correlation with depression, but not with anxiety. Serum level of BDNF increased 
      with depression score in FMS. However, serum level of IL-6 was not correlated 
      with both depression and anxiety scores. Taken together, BDNF is involved in the 
      pathophysiology of FMS. Additionally, it seems to be correlated with intensity of 
      depressive symptoms in FMS.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Nugraha, Boya
AU  - Nugraha B
AD  - Department of Rehabilitation Medicine, Hannover Medical School, Hannover, 
      Germany. Nugraha.Boya@mh-hannover.de
FAU - Korallus, Christoph
AU  - Korallus C
FAU - Gutenbrunner, Christoph
AU  - Gutenbrunner C
LA  - eng
PT  - Journal Article
DEP - 20130111
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anxiety/*blood/complications
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Depression/*blood/complications
MH  - Fibromyalgia/*blood/complications
MH  - Humans
MH  - Interleukin-6/blood
MH  - Middle Aged
EDAT- 2013/01/16 06:00
MHDA- 2013/08/30 06:00
CRDT- 2013/01/16 06:00
PHST- 2012/06/11 00:00 [received]
PHST- 2012/12/14 00:00 [revised]
PHST- 2013/01/04 00:00 [accepted]
PHST- 2013/01/16 06:00 [entrez]
PHST- 2013/01/16 06:00 [pubmed]
PHST- 2013/08/30 06:00 [medline]
AID - S0197-0186(13)00004-1 [pii]
AID - 10.1016/j.neuint.2013.01.001 [doi]
PST - ppublish
SO  - Neurochem Int. 2013 Feb;62(3):281-6. doi: 10.1016/j.neuint.2013.01.001. Epub 2013 
      Jan 11.