PMID- 23319225
OWN - NLM
STAT- MEDLINE
DCOM- 20130404
LR  - 20191112
IS  - 0028-3843 (Print)
IS  - 0028-3843 (Linking)
VI  - 46
IP  - 6
DP  - 2012 Nov-Dec
TI  - Neurotoxicity of lead. Hypothetical molecular mechanisms of synaptic function 
      disorders.
PG  - 569-78
AB  - Lead (Pb) toxicity is still a major health problem associated with both 
      environmental and occupational exposure. Special attention is given to the 
      neurotoxic effect of lead. Along with the newly emerging data, the Pb 
      concentration in the body that can be considered safe is declining. Numerous 
      studies on the neurotoxicity of Pb have shown multiple cellular 'molecular 
      targets' of this metal at the biochemical and molecular levels, and differences 
      in sensitivity to its toxic action among various neural cells. One possible 
      target of the neurotoxic effect of Pb (at the synapse level) is 
      N-methyl-D-aspartic acid (NMDA) receptors. This review presents the hypothetical 
      molecular mechanism by which Pb disrupts synapse formation and plasticity in 
      developing hippocampal neurons and the role of the NMDA receptor-dependent 
      signaling pathway and brain-derived neurotrophic factor (BDNF) as a mechanism of 
      Pb neurotoxicity at the synapse level.
FAU - Baranowska-Bosiacka, Irena
AU  - Baranowska-Bosiacka I
AD  - Katedra Biochemii i Chemii Medycznej, Pomorski Uniwersytet Medyczny w Szczecinie, 
      Szczecin, Polska. ika@sci.pam.szczecin.pl
FAU - Gutowska, Izabela
AU  - Gutowska I
FAU - Rybicka, Marta
AU  - Rybicka M
FAU - Nowacki, Przemyslaw
AU  - Nowacki P
FAU - Chlubek, Dariusz
AU  - Chlubek D
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Poland
TA  - Neurol Neurochir Pol
JT  - Neurologia i neurochirurgia polska
JID - 0101265
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Cognition/drug effects
MH  - Environmental Exposure/adverse effects
MH  - Humans
MH  - Lead Poisoning, Nervous System/*metabolism
MH  - Neuronal Plasticity/drug effects
MH  - Neurons/*drug effects
MH  - Neurotoxicity Syndromes/*metabolism
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Risk Factors
MH  - Synapses/*drug effects
EDAT- 2013/01/16 06:00
MHDA- 2013/04/05 06:00
CRDT- 2013/01/16 06:00
PHST- 2013/01/16 06:00 [entrez]
PHST- 2013/01/16 06:00 [pubmed]
PHST- 2013/04/05 06:00 [medline]
AID - S0028-3843(14)60256-5 [pii]
AID - 10.5114/ninp.2012.31607 [doi]
PST - ppublish
SO  - Neurol Neurochir Pol. 2012 Nov-Dec;46(6):569-78. doi: 10.5114/ninp.2012.31607.