PMID- 23320481
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20211021
IS  - 1477-7827 (Electronic)
IS  - 1477-7827 (Linking)
VI  - 11
DP  - 2013 Jan 15
TI  - Circulating matrix metalloproteinase MMP-9 and MMP-2/TIMP-2 complex are 
      associated with spontaneous early pregnancy failure.
PG  - 2
LID - 10.1186/1477-7827-11-2 [doi]
AB  - BACKGROUND: Trophoblast cell (CTB) invasion into the maternal endometrium plays a 
      crucial role during human embryo implantation and placentation. This invasion is 
      facilitated by the activity of matrix metalloproteinases, which are regulated by 
      tissue inhibitors of MMPs (TIMPs). METHODS: This study compares the serum levels 
      of MMP-9, MMP-2/TIMP-2 complex, TIMP-1 and TIMP-2 in 129 patients with ongoing 
      pregnancy (n = 40) or spontaneous early pregnancy failure (n = 89). RESULTS: 
      MMP-9 was markedly (p < 0.0001) elevated in missed abortions, as was MMP-2/TIMP-2 
      complex (p < 0.0005). However, the serum levels of TIMP-1 and TIMP-2 were 
      markedly elevated (p < 0.0001) in ongoing pregnancies. CONCLUSIONS: Human 
      placentation is mediated by fetal trophoblastic cells that invade the maternal 
      uterine endometrium. Trophoblast invasion requires a precisely regulated 
      secretion of specific proteolytic enzymes able to degrade the endometrial 
      basement membrane and extracellular matrix. The elevated levels of MMP-9 and 
      MMP-2/TIMP-2 complex may play a role in spontaneous termination of pregnancy.
FAU - Nissi, Ritva
AU  - Nissi R
AD  - Department of Obstetrics and Gynecology, Oulu University Hospital, Kajaanintie 
      52A, Oulu, 90220, Finland. ritva.nissi@oulu.fi
FAU - Talvensaari-Mattila, Anne
AU  - Talvensaari-Mattila A
FAU - Kotila, Vesa
AU  - Kotila V
FAU - Niinimaki, Maarit
AU  - Niinimaki M
FAU - Jarvela, Ilkka
AU  - Jarvela I
FAU - Turpeenniemi-Hujanen, Taina
AU  - Turpeenniemi-Hujanen T
LA  - eng
PT  - Journal Article
DEP - 20130115
PL  - England
TA  - Reprod Biol Endocrinol
JT  - Reproductive biology and endocrinology : RB&E
JID - 101153627
RN  - 0 (TIMP1 protein, human)
RN  - 0 (TIMP2 protein, human)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Abortion, Missed/enzymology
MH  - Abortion, Spontaneous/*enzymology
MH  - Adult
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Matrix Metalloproteinase 2/*blood
MH  - Matrix Metalloproteinase 9/*blood
MH  - Placentation/physiology
MH  - Pregnancy
MH  - Tissue Inhibitor of Metalloproteinase-1/*blood
MH  - Tissue Inhibitor of Metalloproteinase-2/*blood
MH  - Trophoblasts/physiology
PMC - PMC3566964
EDAT- 2013/01/17 06:00
MHDA- 2013/07/23 06:00
PMCR- 2013/01/15
CRDT- 2013/01/17 06:00
PHST- 2012/10/14 00:00 [received]
PHST- 2013/01/02 00:00 [accepted]
PHST- 2013/01/17 06:00 [entrez]
PHST- 2013/01/17 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
PHST- 2013/01/15 00:00 [pmc-release]
AID - 1477-7827-11-2 [pii]
AID - 10.1186/1477-7827-11-2 [doi]
PST - epublish
SO  - Reprod Biol Endocrinol. 2013 Jan 15;11:2. doi: 10.1186/1477-7827-11-2.