PMID- 23321006
OWN - NLM
STAT- MEDLINE
DCOM- 20140116
LR  - 20141120
IS  - 0172-6390 (Print)
IS  - 0172-6390 (Linking)
VI  - 60
IP  - 125
DP  - 2013 Jul-Aug
TI  - Status of tissue expression and serum levels of HER2 in gastric cancer patients 
      in Japan.
PG  - 1083-8
LID - 10.5754/hge121022 [doi]
AB  - BACKGROUND: The incidence of HER2 expression in gastric cancer varies among 
      previous studies. Furthermore, serum HER2 levels have not been well studied in 
      patients with gastric cancer. METHODOLOGY: Cancerous gastric tissue was analyzed 
      by immunohistochemistry (IHC) to give an IHC score (IHC0, 1+, 2+ or 3) for HER2 
      expression. Fluorescence in situ hybridization (FISH) was performed to examine 
      HER2 gene expression in IHC2+ cases. Levels of HER2 in serum collected before 
      surgery were determined by chemiluminescent enzyme immunoassay. RESULTS: Subjects 
      were 105 gastric cancer patients who underwent surgical resection. Tissue 
      expression of HER2 was positive (IHC3+, or IHC2+ plus FISH+) in 6.7% of patients 
      (7/105). All HER2-positive tumors were highly differentiated. Mean serum HER2 
      level was 8.7+/-2.1 ng/dl in patients with primary gastric cancer. The mean serum 
      HER2 level in the highly differentiated cancer group was 9.2+/-2.1 ng/dl, which was 
      significantly higher than that (8.1+/-1.9 ng/dl) in the poorly differentiated 
      group. CONCLUSION: Tissue expression of HER2 was found in 6.7% of examined 
      Japanese gastric cancer patients, and all HER2-positive tumors were highly 
      differentiated. Serum HER2 levels were significantly higher in patients with 
      highly differentiated cancer, in good agreement with the higher tissue expression 
      of HER2 in highly differentiated cancer.
FAU - Narita, Toru
AU  - Narita T
FAU - Seshimo, Akiyoshi
AU  - Seshimo A
FAU - Suzuki, Mamoru
AU  - Suzuki M
FAU - Murata, Jun
AU  - Murata J
FAU - Kameoka, Shingo
AU  - Kameoka S
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Hepatogastroenterology
JT  - Hepato-gastroenterology
JID - 8007849
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Receptor, ErbB-2/*analysis/blood
MH  - Stomach Neoplasms/blood/*chemistry/pathology
EDAT- 2013/01/17 06:00
MHDA- 2014/01/17 06:00
CRDT- 2013/01/17 06:00
PHST- 2013/01/17 06:00 [entrez]
PHST- 2013/01/17 06:00 [pubmed]
PHST- 2014/01/17 06:00 [medline]
AID - 10.5754/hge121022 [doi]
PST - ppublish
SO  - Hepatogastroenterology. 2013 Jul-Aug;60(125):1083-8. doi: 10.5754/hge121022.