PMID- 23322300
OWN - NLM
STAT- MEDLINE
DCOM- 20130308
LR  - 20211021
IS  - 1549-5477 (Electronic)
IS  - 0890-9369 (Print)
IS  - 0890-9369 (Linking)
VI  - 27
IP  - 2
DP  - 2013 Jan 15
TI  - FGF7 is a functional niche signal required for stimulation of adult liver 
      progenitor cells that support liver regeneration.
PG  - 169-81
LID - 10.1101/gad.204776.112 [doi]
AB  - The liver is a unique organ with a remarkably high potential to regenerate upon 
      injuries. In severely damaged livers where hepatocyte proliferation is impaired, 
      facultative liver progenitor cells (LPCs) proliferate and are assumed to 
      contribute to regeneration. An expansion of LPCs is often observed in patients 
      with various types of liver diseases. However, the underlying mechanism of LPC 
      activation still remains largely unknown. Here we show that a member of the 
      fibroblast growth factor (FGF) family, FGF7, is a critical regulator of LPCs. Its 
      expression was induced concomitantly with LPC response in the liver of mouse 
      models as well as in the serum of patients with acute liver failure. 
      Fgf7-deficient mice exhibited markedly depressed LPC expansion and higher 
      mortality upon toxin-induced hepatic injury. Transgenic expression of FGF7 in 
      vivo led to the induction of cells with characteristics of LPCs and ameliorated 
      hepatic dysfunction. We revealed that Thy1(+) mesenchymal cells produced FGF7 and 
      appeared in close proximity to LPCs, implicating a role for those cells as the 
      functional LPC niche in the regenerating liver. These findings provide new 
      insights into the cellular and molecular basis for LPC regulation and identify 
      FGF7 as a potential therapeutic target for liver diseases.
FAU - Takase, Hinako M
AU  - Takase HM
AD  - Laboratory of Cell Growth and Differentiation, Institute of Molecular and 
      Cellular Biosciences, The University of Tokyo, Tokyo, Japan.
FAU - Itoh, Tohru
AU  - Itoh T
FAU - Ino, Seitaro
AU  - Ino S
FAU - Wang, Ting
AU  - Wang T
FAU - Koji, Takehiko
AU  - Koji T
FAU - Akira, Shizuo
AU  - Akira S
FAU - Takikawa, Yasuhiro
AU  - Takikawa Y
FAU - Miyajima, Atsushi
AU  - Miyajima A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130115
PL  - United States
TA  - Genes Dev
JT  - Genes & development
JID - 8711660
RN  - 0 (Fgf7 protein, mouse)
RN  - 0 (Thy-1 Antigens)
RN  - 126469-10-1 (Fibroblast Growth Factor 7)
SB  - IM
MH  - Animals
MH  - Cell Proliferation
MH  - Fibroblast Growth Factor 7/genetics/*metabolism
MH  - Hepatocytes/*cytology/metabolism
MH  - Liver Diseases/physiopathology
MH  - Liver Regeneration/*physiology
MH  - Mice
MH  - *Signal Transduction
MH  - Stem Cells/*cytology/metabolism
MH  - Thy-1 Antigens/metabolism
MH  - Up-Regulation
PMC - PMC3566310
EDAT- 2013/01/17 06:00
MHDA- 2013/03/09 06:00
PMCR- 2013/07/15
CRDT- 2013/01/17 06:00
PHST- 2013/01/17 06:00 [entrez]
PHST- 2013/01/17 06:00 [pubmed]
PHST- 2013/03/09 06:00 [medline]
PHST- 2013/07/15 00:00 [pmc-release]
AID - gad.204776.112 [pii]
AID - 10.1101/gad.204776.112 [doi]
PST - ppublish
SO  - Genes Dev. 2013 Jan 15;27(2):169-81. doi: 10.1101/gad.204776.112. Epub 2013 Jan 
      15.