PMID- 23322304
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20211021
IS  - 1432-1963 (Electronic)
IS  - 0172-8113 (Linking)
VI  - 34
IP  - 1
DP  - 2013 Feb
TI  - [Myelodysplastic syndromes. Epidemiology, molecular and morphological 
      characteristics and risk stratification].
PG  - 45-55
LID - 10.1007/s00292-012-1707-4 [doi]
AB  - Myelodysplastic syndromes (MDS) comprise a spectrum of clonal stem cell disorders 
      which are currently defined according to the classification scheme of the revised 
      2008 WHO classification but which may be further refined in the future. The 
      clinical presentation is often characterized by unexplained isolated or multiple 
      peripheral blood cytopenias resulting in anemia, bleeding events or increased 
      susceptibility to infections. The generally hypercellular, but rarely 
      hypocellular and occasionally fibrotic bone marrow shows dysplastic features in 
      >/= 10 % of cells of at least one of the hematopoietic lineages. These features and 
      enhanced apoptosis, stem cell senescence and immunologic dysregulation result in 
      ineffective hematopoiesis. Diagnostics in MDS relies on complementary 
      consideration of hematological, morphological and cytogenetic/molecular 
      parameters. Methods include marrow and peripheral blood cytology, cytogenetics, 
      fluorescence in situ hybridization (FISH), trephine bone marrow biopsy 
      examination, immunophenotyping and the evaluation of molecular markers by 
      established and new techniques. Mutations affecting growth factor receptors, cell 
      cycle and apoptosis regulators, intracellular signaling, transcription factors, 
      epigenetic regulation and the splicosome are involved in MDS pathogenesis and 
      progression.
FAU - Schmitt-Graeff, A H
AU  - Schmitt-Graeff AH
AD  - Institut fur Pathologie, Universitatsklinikum Freiburg, Breisacherstr. 115a, 
      79106, Freiburg, Deutschland. annette.schmitt-graeff@uniklinik-freiburg.de
FAU - Muller, M J
AU  - Muller MJ
FAU - Fisch, P
AU  - Fisch P
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Myelodysplastische Syndrome. Epidemiologie, molekulare und morphologische 
      Merkmale, Risikostratifizierung.
PL  - Germany
TA  - Pathologe
JT  - Der Pathologe
JID - 8006541
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/genetics
MH  - Biopsy, Needle
MH  - Blood Cells/pathology
MH  - Bone Marrow/pathology
MH  - Cross-Sectional Studies
MH  - Cytogenetic Analysis/methods
MH  - DNA Mutational Analysis/methods
MH  - Hematopoietic Stem Cells/pathology
MH  - Humans
MH  - Immunophenotyping/methods
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Myelodysplastic Syndromes/classification/epidemiology/*genetics/*pathology
MH  - Prognosis
MH  - Risk Factors
EDAT- 2013/01/17 06:00
MHDA- 2013/08/27 06:00
CRDT- 2013/01/17 06:00
PHST- 2013/01/17 06:00 [entrez]
PHST- 2013/01/17 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - 10.1007/s00292-012-1707-4 [doi]
PST - ppublish
SO  - Pathologe. 2013 Feb;34(1):45-55. doi: 10.1007/s00292-012-1707-4.