PMID- 23324575
OWN - NLM
STAT- MEDLINE
DCOM- 20130821
LR  - 20221207
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 34
IP  - 2
DP  - 2013
TI  - Novel ERBB receptor feedback inhibitor 1 (ERRFI1) + 808 T/G polymorphism confers 
      protective effect on diabetic nephropathy in a Korean population.
PG  - 113-24
LID - 10.3233/DMA-120949 [doi]
AB  - BACKGROUND: The identification and characterization of the gene, ERRFI1, in 
      diabetes has not been reported. In this study, we evaluated the relationship 
      between ERRFI1 polymorphism and characteristics of type 2 diabetes mellitus 
      (T2DM) in Korea. SUBJECTS AND METHODS: We conduct a case-control study involving 
      T2DM patients (n=342) and controls (n=473). RESULTS: A novel single nucleotide 
      ERRFI1 gene polymorphism at +807(T/G) was found. G genotype frequency was 40.1% 
      in the diabetic group and 42.7% in the control group; the difference was not 
      significant (p=0.45). In the diabetic group, the urine albumin to creatinine 
      ratio (ACR) was lower in the G genotype than in the T genotype (P=0.004). In 
      males with T2DM, those with the G genotype displayed lower systolic blood 
      pressure (P=0.01) and higher glomerular filtration rate (P=0.048) compare to 
      those with the T genotype. In females with T2DM, urine ACR was low in those with 
      the G genotype than in those with the T genotype (P=0.02). In the diabetic group, 
      patients who harboring T allele had a 1.81 times higher risk of diabetic 
      nephropathy than the G allele (95% CI 1.11-2.96, P=0.02). In females with T2DM, 
      patients who harboring T allele had a 2.12 times higher risk of diabetic 
      nephropathy (95% CI 1.07-4.1, P=0.03). CONCLUSIONS: We identify new loci 
      associated with glycemic traits in diabetes and this finding indicates the 
      potential of ERRFI1 as a novel therapeutic target of diabetic nephropathy.
FAU - Lee, Ihn Suk
AU  - Lee IS
AD  - Department of Internal Medicine, The Catholic University College of Medicine, 
      Daejeon, Korea.
FAU - Lee, Ju Hee
AU  - Lee JH
FAU - Kim, Hyun Jin
AU  - Kim HJ
FAU - Lee, Jae Min
AU  - Lee JM
FAU - Lee, Seong Kyu
AU  - Lee SK
FAU - Kim, Hye Soo
AU  - Kim HS
FAU - Lee, Jong Min
AU  - Lee JM
FAU - Park, Kang Seo
AU  - Park KS
FAU - Ku, Bon Jeong
AU  - Ku BJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (ERRFI1 protein, human)
RN  - 0 (Tumor Suppressor Proteins)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/*genetics
MH  - Adult
MH  - Aged
MH  - Albuminuria/genetics
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Creatinine/urine
MH  - Diabetes Mellitus, Type 2/complications/genetics
MH  - Diabetic Nephropathies/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Glomerular Filtration Rate/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Tumor Suppressor Proteins/*genetics
PMC - PMC3809977
EDAT- 2013/01/18 06:00
MHDA- 2013/08/22 06:00
PMCR- 2013/01/24
CRDT- 2013/01/18 06:00
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/08/22 06:00 [medline]
PHST- 2013/01/24 00:00 [pmc-release]
AID - 9412658748853857 [pii]
AID - 10.3233/DMA-120949 [doi]
PST - ppublish
SO  - Dis Markers. 2013;34(2):113-24. doi: 10.3233/DMA-120949.