PMID- 23324862
OWN - NLM
STAT- MEDLINE
DCOM- 20130925
LR  - 20161125
IS  - 1348-4214 (Electronic)
IS  - 0916-9636 (Linking)
VI  - 36
IP  - 4
DP  - 2013 Apr
TI  - Increased oxygen free radical production during pregnancy may impair vascular 
      reactivity in preeclamptic women.
PG  - 356-60
LID - 10.1038/hr.2012.208 [doi]
AB  - To determine whether enhanced oxidative stress during pregnancy impairs vascular 
      endothelial function and improves after delivery in preeclamptic women, we 
      measured serum parameters of oxidative stress and endothelial function during 
      pregnancy and 1 month after delivery in women with or without preeclampsia. We 
      evaluated 18 participants with uncomplicated pregnancies, 11 with mild 
      preeclampsia and 13 with severe preeclampsia. The plasma concentrations of 
      reactive oxygen metabolite derivatives (d-ROMs) were measured, and the biological 
      antioxidant potential (BAP) was determined to evaluate the oxygen free radicals 
      and antioxidants, respectively. Flow-mediated vasodilation (FMD) was also 
      assessed as a marker of endothelial function. FMD was decreased significantly in 
      both preeclamptic groups compared with control during pregnancy. FMD did not 
      change after delivery in the control group, but it significantly increased after 
      delivery in both the mildly and severely preeclamptic groups, nearing control 
      levels 1 month after delivery (mild, 6.5+/-3.6-9.0+/-3.5%; severe, 4.3+/-3.3-9.7+/-2.6%). 
      No changes in d-ROM concentrations were observed in the control group; however, 
      the concentrations in both the mildly and severely preeclamptic groups 
      significantly decreased to normal levels 1 month after delivery (mild, 
      562.0+/-106.5-430.5+/-90.5 CARR U (Carratelli units); severe, 681.0+/-239.0-411.8+/-69.7 
      CARR U). The plasma BAP levels did not change significantly in all three groups. 
      A negative correlation between FMD and d-ROM concentrations was observed in the 
      preeclamptic group, but not in the control group (r=-0.497; P<0.05). Our findings 
      indicated that enhanced oxidative stress during pregnancy may impair endothelial 
      function and improve after delivery in preeclamptic women.
FAU - Watanabe, Kazushi
AU  - Watanabe K
AD  - Department of Obstetrics and Gynecology, Aichi Medical University School of 
      Medicine, Aichi, Japan. kw446433@yahoo.co.jp
FAU - Mori, Toshitaka
AU  - Mori T
FAU - Iwasaki, Ai
AU  - Iwasaki A
FAU - Kimura, Chiharu
AU  - Kimura C
FAU - Matsushita, Hiroshi
AU  - Matsushita H
FAU - Shinohara, Koichi
AU  - Shinohara K
FAU - Wakatsuki, Akihiko
AU  - Wakatsuki A
LA  - eng
PT  - Journal Article
DEP - 20130117
PL  - England
TA  - Hypertens Res
JT  - Hypertension research : official journal of the Japanese Society of Hypertension
JID - 9307690
RN  - 0 (Antioxidants)
RN  - 0 (Free Radicals)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Adult
MH  - Antioxidants/metabolism
MH  - Blood Pressure/physiology
MH  - Endothelium, Vascular/physiology
MH  - Female
MH  - Free Radicals/*metabolism
MH  - Gestational Age
MH  - Humans
MH  - Maternal Age
MH  - Muscle, Smooth, Vascular/diagnostic imaging/*physiology
MH  - Oxidative Stress/physiology
MH  - Pre-Eclampsia/diagnostic imaging/*metabolism/physiopathology
MH  - Pregnancy
MH  - Reactive Oxygen Species/*metabolism
MH  - Ultrasonography, Doppler
EDAT- 2013/01/18 06:00
MHDA- 2013/09/26 06:00
CRDT- 2013/01/18 06:00
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/09/26 06:00 [medline]
AID - hr2012208 [pii]
AID - 10.1038/hr.2012.208 [doi]
PST - ppublish
SO  - Hypertens Res. 2013 Apr;36(4):356-60. doi: 10.1038/hr.2012.208. Epub 2013 Jan 17.