PMID- 2332519
OWN - NLM
STAT- MEDLINE
DCOM- 19900606
LR  - 20190501
IS  - 0021-9746 (Print)
IS  - 1472-4146 (Electronic)
IS  - 0021-9746 (Linking)
VI  - 43
IP  - 3
DP  - 1990 Mar
TI  - Role of nucleolar organiser regions in differentiating malignant from benign 
      tumours of the colon.
PG  - 235-8
AB  - An argyrophilic technique (AgNOR) was applied to paraffin wax sections of 12 
      tubular adenomas, 17 villous adenomas with moderate and severe atypia, and 21 
      colonic adenocarcinomas. The range of the mean number of nucleolar organiser 
      regions (NORS) per nucleus was 1.54-3.28 (99% CI 2.29-3.04) for tubular adenomas 
      3.07-4.36 (2.98-4.43), and 3.60-5.02 (3.74-4.69) for villous adenomas with 
      moderate and severe atypia, respectively, and 5.53-9.33 (6.15-8.54) for highly 
      differentiated adenocarcinomas. The number of AgNORs permitted differentiation 
      among the three groups. The differences observed were significant. Malignant 
      tumour cells were characterised by a large number of AgNORs which were small in 
      size and showed a scattered distribution. Nuclei of tubular adenoma and villous 
      adenoma with moderate atypia had only a small number of large sized AgNORs in a 
      clustered distribution. It is suggested that this method distinguishes malignant 
      epithelial cells from benign cells of colon, even those with severe atypia, and 
      that it is a useful adjunct to diagnostic histopathology.
FAU - Yang, P
AU  - Yang P
AD  - Department of Pathology, Fourth Military Medical University, People's Republic of 
      China.
FAU - Huang, G S
AU  - Huang GS
FAU - Zhu, X S
AU  - Zhu XS
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Clin Pathol
JT  - Journal of clinical pathology
JID - 0376601
SB  - IM
MH  - Adenocarcinoma/pathology
MH  - Adenoma/pathology
MH  - Colonic Neoplasms/diagnosis/*pathology
MH  - Diagnosis, Differential
MH  - Humans
MH  - Nucleolus Organizer Region/*pathology
PMC - PMC502337
EDAT- 1990/03/01 00:00
MHDA- 1990/03/01 00:01
PMCR- 1993/03/01
CRDT- 1990/03/01 00:00
PHST- 1990/03/01 00:00 [pubmed]
PHST- 1990/03/01 00:01 [medline]
PHST- 1990/03/01 00:00 [entrez]
PHST- 1993/03/01 00:00 [pmc-release]
AID - 10.1136/jcp.43.3.235 [doi]
PST - ppublish
SO  - J Clin Pathol. 1990 Mar;43(3):235-8. doi: 10.1136/jcp.43.3.235.