PMID- 23325216
OWN - NLM
STAT- MEDLINE
DCOM- 20130304
LR  - 20220410
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 493
IP  - 7432
DP  - 2013 Jan 17
TI  - mTOR is a key modulator of ageing and age-related disease.
PG  - 338-45
LID - 10.1038/nature11861 [doi]
AB  - Many experts in the biology of ageing believe that pharmacological interventions 
      to slow ageing are a matter of 'when' rather than 'if'. A leading target for such 
      interventions is the nutrient response pathway defined by the mechanistic target 
      of rapamycin (mTOR). Inhibition of this pathway extends lifespan in model 
      organisms and confers protection against a growing list of age-related 
      pathologies. Characterized inhibitors of this pathway are already clinically 
      approved, and others are under development. Although adverse side effects 
      currently preclude use in otherwise healthy individuals, drugs that target the 
      mTOR pathway could one day become widely used to slow ageing and reduce 
      age-related pathologies in humans.
FAU - Johnson, Simon C
AU  - Johnson SC
AD  - Department of Pathology, University of Washington, Seattle, Washington 98195, 
      USA.
FAU - Rabinovitch, Peter S
AU  - Rabinovitch PS
FAU - Kaeberlein, Matt
AU  - Kaeberlein M
LA  - eng
GR  - R01AG031108/AG/NIA NIH HHS/United States
GR  - T32AG000057/AG/NIA NIH HHS/United States
GR  - P01 AG001751/AG/NIA NIH HHS/United States
GR  - R01 AG039390/AG/NIA NIH HHS/United States
GR  - T32 AG000057/AG/NIA NIH HHS/United States
GR  - R01AG039390/AG/NIA NIH HHS/United States
GR  - P30 AG013280/AG/NIA NIH HHS/United States
GR  - R01 AG038550/AG/NIA NIH HHS/United States
GR  - R01 AG031108/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Insulin)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Aging/*metabolism/pathology
MH  - Animals
MH  - Humans
MH  - Insulin/metabolism
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Longevity/genetics
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC3687363
MID - NIHMS475301
EDAT- 2013/01/18 06:00
MHDA- 2013/03/05 06:00
PMCR- 2013/07/17
CRDT- 2013/01/18 06:00
PHST- 2012/06/25 00:00 [received]
PHST- 2012/11/13 00:00 [accepted]
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/03/05 06:00 [medline]
PHST- 2013/07/17 00:00 [pmc-release]
AID - nature11861 [pii]
AID - 10.1038/nature11861 [doi]
PST - ppublish
SO  - Nature. 2013 Jan 17;493(7432):338-45. doi: 10.1038/nature11861.