PMID- 23325250
OWN - NLM
STAT- MEDLINE
DCOM- 20130401
LR  - 20231013
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 33
IP  - 3
DP  - 2013 Jan 16
TI  - Different roles of BDNF in nucleus accumbens core versus shell during the 
      incubation of cue-induced cocaine craving and its long-term maintenance.
PG  - 1130-42
LID - 10.1523/JNEUROSCI.3082-12.2013 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) contributes to diverse types of 
      plasticity, including cocaine addiction. We investigated the role of BDNF in the 
      rat nucleus accumbens (NAc) in the incubation of cocaine craving over 3 months of 
      withdrawal from extended access cocaine self-administration. First, we confirmed 
      by immunoblotting that BDNF levels are elevated after this cocaine regimen on 
      withdrawal day 45 (WD45) and showed that BDNF mRNA levels are not altered. Next, 
      we explored the time course of elevated BDNF expression using 
      immunohistochemistry. Elevation of BDNF in the NAc core was detected on WD45 and 
      further increased on WD90, whereas elevation in shell was not detected until 
      WD90. Surface expression of activated tropomyosin receptor kinase B (TrkB) was 
      also enhanced on WD90. Next, we used viral vectors to attenuate BDNF-TrkB 
      signaling. Virus injection into the NAc core enhanced cue-induced cocaine seeking 
      on WD1 compared with controls, whereas no effect was observed on WD30 or WD90. 
      Attenuating BDNF-TrkB signaling in shell did not affect cocaine seeking on WD1 or 
      WD45 but significantly decreased cocaine seeking on WD90. These results suggest 
      that basal levels of BDNF transmission in the NAc core exert a suppressive effect 
      on cocaine seeking in early withdrawal (WD1), whereas the late elevation of BDNF 
      protein in NAc shell contributes to incubation in late withdrawal (WD90). 
      Finally, BDNF protein levels in the NAc were significantly increased after 
      ampakine treatment, supporting the novel hypothesis that the gradual increase of 
      BDNF levels in NAc accompanying incubation could be caused by increased AMPAR 
      transmission during withdrawal.
FAU - Li, Xuan
AU  - Li X
AD  - Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 
      North Chicago, Illinois 60064, USA.
FAU - DeJoseph, M R
AU  - DeJoseph MR
FAU - Urban, Janice H
AU  - Urban JH
FAU - Bahi, Amine
AU  - Bahi A
FAU - Dreyer, Jean-Luc
AU  - Dreyer JL
FAU - Meredith, Gloria E
AU  - Meredith GE
FAU - Ford, Kerstin A
AU  - Ford KA
FAU - Ferrario, Carrie R
AU  - Ferrario CR
FAU - Loweth, Jessica A
AU  - Loweth JA
FAU - Wolf, Marina E
AU  - Wolf ME
LA  - eng
GR  - F32 DA024502/DA/NIDA NIH HHS/United States
GR  - K05 DA029099/DA/NIDA NIH HHS/United States
GR  - R01 DA015835/DA/NIDA NIH HHS/United States
GR  - DA015835/DA/NIDA NIH HHS/United States
GR  - F32 DA030844/DA/NIDA NIH HHS/United States
GR  - R37 DA015835/DA/NIDA NIH HHS/United States
GR  - DA029099/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine Uptake Inhibitors)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Cocaine/*administration & dosage/adverse effects
MH  - Cocaine-Related Disorders/*metabolism
MH  - Conditioning, Operant/drug effects
MH  - Cues
MH  - Dopamine Uptake Inhibitors/*administration & dosage
MH  - Male
MH  - Nucleus Accumbens/drug effects/*metabolism
MH  - Phosphorylation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/metabolism
MH  - Self Administration
MH  - Substance Withdrawal Syndrome/*metabolism
PMC - PMC3711541
MID - NIHMS436777
EDAT- 2013/01/18 06:00
MHDA- 2013/04/02 06:00
PMCR- 2013/07/16
CRDT- 2013/01/18 06:00
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/04/02 06:00 [medline]
PHST- 2013/07/16 00:00 [pmc-release]
AID - 33/3/1130 [pii]
AID - 3817977 [pii]
AID - 10.1523/JNEUROSCI.3082-12.2013 [doi]
PST - ppublish
SO  - J Neurosci. 2013 Jan 16;33(3):1130-42. doi: 10.1523/JNEUROSCI.3082-12.2013.