PMID- 23326309
OWN - NLM
STAT- MEDLINE
DCOM- 20130705
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 1
DP  - 2013
TI  - Functional promoter -308G>A variant in tumor necrosis factor alpha gene is associated 
      with risk and progression of gastric cancer in a Chinese population.
PG  - e50856
LID - 10.1371/journal.pone.0050856 [doi]
LID - e50856
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) plays a crucial role in the 
      development and progression of gastric cancer. A functional polymorphism, -308 
      G>A (rs1800629), which is located in the promoter of TNFA gene, has been 
      suggested to alter the production of TNF-alpha and influence cancer risk. In the 
      present study, we sought to investigate whether this polymorphism has effects on 
      the risk and progression of gastric cancer in a Chinese population. METHODS: We 
      genotyped the TNFA -308 G>A polymorphism using the TaqMan method in a two-stage 
      case-control study comprising a total of 1686 gastric cancer patients and 1895 
      cancer-free subjects. The logistic regression was used to assess the genetic 
      associations with occurrence and progression of gastric cancer. RESULTS: We found 
      a significant association between the variant genotypes and increased risk of 
      gastric cancer [P = 0.034, odds ratio (OR) = 1.39, 95% confidence interval 
      (CI) = 1.01-1.67, GA/AA vs. GG]. Similar results were observed in the follow-up 
      replication study. When combined the data from the two studies, we found a more 
      significant association (P = 0.001, OR = 1.34, 95%CI = 1.13-1.59), especially for 
      older subjects (>65 years). Furthermore, the patients carrying the variant 
      genotypes had a significantly greater prevalence of T4 stage of disease 
      (P = 0.001, OR = 2.19, 95%CI = 1.39-3.47) and distant metastasis (P = 0.013, 
      OR = 1.61, 95%CI = 1.10-2.35). CONCLUSIONS: Our results suggest that the 
      functional promoter -308 G>A polymorphism in TNFA influence the susceptibility 
      and progression of gastric cancer in the Chinese population.
FAU - Hong, Yan
AU  - Hong Y
AD  - Department of Surgery, Yixing People's Hospital, Yixing, China.
FAU - Ge, Zhijun
AU  - Ge Z
FAU - Jing, Changrui
AU  - Jing C
FAU - Shi, Jun
AU  - Shi J
FAU - Dong, Xiao
AU  - Dong X
FAU - Zhou, Fengying
AU  - Zhou F
FAU - Wang, Meilin
AU  - Wang M
FAU - Zhang, Zhengdong
AU  - Zhang Z
FAU - Gong, Weida
AU  - Gong W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130110
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Asian People/genetics
MH  - China
MH  - Disease Progression
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/ethnology/*genetics
MH  - Genotype
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/*genetics
MH  - Risk Factors
MH  - Stomach Neoplasms/ethnology/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
PMC - PMC3542372
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/01/18 06:00
MHDA- 2013/07/06 06:00
PMCR- 2013/01/10
CRDT- 2013/01/18 06:00
PHST- 2012/05/27 00:00 [received]
PHST- 2012/10/29 00:00 [accepted]
PHST- 2013/01/18 06:00 [entrez]
PHST- 2013/01/18 06:00 [pubmed]
PHST- 2013/07/06 06:00 [medline]
PHST- 2013/01/10 00:00 [pmc-release]
AID - PONE-D-12-14917 [pii]
AID - 10.1371/journal.pone.0050856 [doi]
PST - ppublish
SO  - PLoS One. 2013;8(1):e50856. doi: 10.1371/journal.pone.0050856. Epub 2013 Jan 10.