PMID- 23327060
OWN - NLM
STAT- MEDLINE
DCOM- 20130416
LR  - 20200929
IS  - 0392-2936 (Print)
IS  - 0392-2936 (Linking)
VI  - 33
IP  - 6
DP  - 2012
TI  - Analysis of epidermal growth factor receptor (EGFR) status in endometrial stromal 
      sarcoma.
PG  - 629-32
AB  - PURPOSE: Endometrial stromal sarcomas (ESSs) are rare neoplasms, which are 
      currently treated by surgery, whereas effective adjuvant therapies have not yet 
      been established. Recently, epidermal growth factor receptor (EGFR) expression 
      has been described in ESS, and a potential role of EGFR-targeted adjuvant 
      therapies has been proposed. The aim of this study was to analyze EGFR status in 
      an ESS series and to evaluate their potential role as molecular targets. 
      MATERIALS AND METHODS: EGFR status was investigated in a total of ten cases of 
      ESS, which included seven low-grade ESS and three undifferentiated ESS cases. 
      EGFR expression levels were assessed by immunohistochemistry, and gene 
      amplification analysis was performed with dual-color fluorescence in situ 
      hybridization (FISH). RESULTS: Nine out of ten ESS cases showed positive 
      immunostaining, whereas FISH analysis demonstrated constantly negative results. 
      CONCLUSIONS: This study confirmed that EGFR is frequently overexpressed in ESS. 
      FISH analysis did not show EGFR amplification in any of the tumors, therefore 
      EGFR expression in ESS should be related to different genetic mechanisms.
FAU - Capobianco, G
AU  - Capobianco G
AD  - Gynecologic and Obstetric Clinic, University of Sassari, Italy.
FAU - Pili, F
AU  - Pili F
FAU - Contini, M
AU  - Contini M
FAU - De Miglio, M R
AU  - De Miglio MR
FAU - Marras, V
AU  - Marras V
FAU - Santeufemia, D A
AU  - Santeufemia DA
FAU - Cherchi, C
AU  - Cherchi C
FAU - Dessole, M
AU  - Dessole M
FAU - Cherchi, P L
AU  - Cherchi PL
FAU - Cossu-Rocca, P
AU  - Cossu-Rocca P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Eur J Gynaecol Oncol
JT  - European journal of gynaecological oncology
JID - 8100357
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Endometrial Neoplasms/*chemistry
MH  - ErbB Receptors/*analysis/genetics
MH  - Female
MH  - Gene Amplification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Middle Aged
MH  - Sarcoma, Endometrial Stromal/*chemistry
EDAT- 2013/01/19 06:00
MHDA- 2013/04/17 06:00
CRDT- 2013/01/19 06:00
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2013/04/17 06:00 [medline]
PST - ppublish
SO  - Eur J Gynaecol Oncol. 2012;33(6):629-32.