PMID- 23327868
OWN - NLM
STAT- MEDLINE
DCOM- 20140115
LR  - 20220317
IS  - 1999-6187 (Electronic)
IS  - 1009-3419 (Print)
IS  - 1009-3419 (Linking)
VI  - 16
IP  - 1
DP  - 2013 Jan
TI  - [Expressions and significances of CRABPII and E-FABP in non-small cell lung 
      cancer].
PG  - 12-9
LID - 10.3779/j.issn.1009-3419.2013.01.03 [doi]
AB  - BACKGROUND: The cellular retinoic acid-binding protein II (CRABPII) and epidermal 
      fatty acid-binding protein (E-FABP) both serving as the transport protein of 
      retinoic acid (RA), through RA signal transduction pathway, commit the cell to 
      opposite fate, apoptosis or survival. The aim of this study is to investigate the 
      expression of CRABPII and E-FABP and significance in non-small cell lung cancer 
      (NSCLC) and their lymph node metastases with tissue microarray technique. 
      METHODS: CRABPII and E-FABP proteins were detected in 54 normal lung tissues, 287 
      primary NSCLC tissues and 112 lymph node metastatic tissues by SP method of 
      immunohistochemical staining. RESULTS: The expression level of CRABPII in the 
      primary lesions was relevant to the gender of NSCLC patients, the metastasis and 
      TNM staging of NSCLC (P<0.05), while the expression level of E-FABP was related 
      to the grading and metastasis of NSCLC (P<0.05). The positive expression rate of 
      E-FABP in NSCLC primary lesion was remarkably higher than that in adjacent normal 
      lung tissues and lymph node metastases, respectively (P<0.05). The expression 
      level of E-FABP had a recognizable advantage over that of CRABPII in NSCLC 
      primary lesions (P<0.05). The differential expressions between CRABPII and E-FABP 
      was correlated with the tumor size, grading, metastasis, TNM staging of NSCLC 
      (P<0.05). The larger the tumor was and the later the TNM staging was, along with 
      cancer metastasis, the more likely the expression of E-FABP would dominate. The 
      expression of CRABPII and difference expression between CRABPII and E-FABP were 
      closely related to the prognosis of NSCLC patients based on Kaplan-Meier survival 
      analysis. CONCLUSIONS: E-FABP showed high exp ression in NSCLC, and the increased 
      E-FABP expression may involved in the occurrence and development of NSCLC. 
      CRABPII might have a negative effect in NSCLC progression, and its expression was 
      negatively related to the prognosis of NSCLC patients.
FAU - Liu, Qian
AU  - Liu Q
AD  - Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, 
      China.
FAU - Wang, Shifeng
AU  - Wang S
FAU - Xu, Huan
AU  - Xu H
FAU - Zhang, Shangfu
AU  - Zhang S
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhongguo Fei Ai Za Zhi
JT  - Zhongguo fei ai za zhi = Chinese journal of lung cancer
JID - 101126433
RN  - 0 (FABP5 protein, human)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (retinoic acid binding protein II, cellular)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Carcinoma, Non-Small-Cell Lung/diagnosis/*metabolism/pathology
MH  - Fatty Acid-Binding Proteins/*metabolism
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lung/cytology/metabolism/pathology
MH  - Lung Neoplasms/diagnosis/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Receptors, Retinoic Acid/*metabolism
PMC - PMC6000456
EDAT- 2013/01/19 06:00
MHDA- 2014/01/16 06:00
PMCR- 2013/01/20
CRDT- 2013/01/19 06:00
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2014/01/16 06:00 [medline]
PHST- 2013/01/20 00:00 [pmc-release]
AID - zgfazz-16-1-12 [pii]
AID - 10.3779/j.issn.1009-3419.2013.01.03 [doi]
PST - ppublish
SO  - Zhongguo Fei Ai Za Zhi. 2013 Jan;16(1):12-9. doi: 
      10.3779/j.issn.1009-3419.2013.01.03.