PMID- 23327934
OWN - NLM
STAT- MEDLINE
DCOM- 20141201
LR  - 20220330
IS  - 1749-5024 (Electronic)
IS  - 1749-5016 (Print)
IS  - 1749-5016 (Linking)
VI  - 9
IP  - 4
DP  - 2014 Apr
TI  - Cognitive behavioral therapy for depression changes medial prefrontal and ventral 
      anterior cingulate cortex activity associated with self-referential processing.
PG  - 487-93
LID - 10.1093/scan/nst009 [doi]
AB  - Cognitive behavioral therapy (CBT), an effective treatment for depression, 
      targets self-referential processing of emotional stimuli. We examined the effects 
      of CBT on brain functioning during self-referential processing in depressive 
      patients using functional magnetic resonance imaging (fMRI). Depressive patients 
      (n = 23) and healthy participants (n = 15) underwent fMRI scans during a 
      self-referential task using emotional trait words. The depressive patients had 
      fMRI scans before and after completing a total of 12 weekly sessions of group CBT 
      for depression, whereas the healthy participants underwent fMRI scans 12 weeks 
      apart with no intervention. Before undergoing CBT, the depressive patients showed 
      hyperactivity in the medial prefrontal cortex (MPFC) during self-referential 
      processing of negative words. Following CBT, MPFC and ventral anterior cingulate 
      cortex (vACC) activity during self-referential processing among depressive 
      patients was increased for positive stimuli, whereas it was decreased for 
      negative stimuli. Improvements in depressive symptoms were negatively correlated 
      with vACC activity during self-referential processing of negative stimuli. These 
      results suggest that CBT-related improvements in depressive symptoms are 
      associated with changes in MPFC and vACC activation during self-referential 
      processing of emotional stimuli.
FAU - Yoshimura, Shinpei
AU  - Yoshimura S
AD  - Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, 
      Minami-ku, Hiroshima 734-8553, Japan. syoshimura1981@hotmail.co.jp.
FAU - Okamoto, Yasumasa
AU  - Okamoto Y
FAU - Onoda, Keiichi
AU  - Onoda K
FAU - Matsunaga, Miki
AU  - Matsunaga M
FAU - Okada, Go
AU  - Okada G
FAU - Kunisato, Yoshihiko
AU  - Kunisato Y
FAU - Yoshino, Atsuo
AU  - Yoshino A
FAU - Ueda, Kazutaka
AU  - Ueda K
FAU - Suzuki, Shin-ichi
AU  - Suzuki S
FAU - Yamawaki, Shigeto
AU  - Yamawaki S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130117
PL  - England
TA  - Soc Cogn Affect Neurosci
JT  - Social cognitive and affective neuroscience
JID - 101288795
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Cognitive Behavioral Therapy/*methods
MH  - Depression/pathology/*rehabilitation
MH  - Female
MH  - Follow-Up Studies
MH  - Gyrus Cinguli/*blood supply
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Judgment
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Oxygen/blood
MH  - Prefrontal Cortex/*blood supply
MH  - Psychiatric Status Rating Scales
MH  - *Self Report
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC3989129
OTO - NOTNLM
OT  - cognitive behavioral therapy
OT  - depression
OT  - emotion
OT  - fMRI
OT  - self-referential processing
EDAT- 2013/01/19 06:00
MHDA- 2014/12/15 06:00
PMCR- 2015/04/01
CRDT- 2013/01/19 06:00
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2015/04/01 00:00 [pmc-release]
AID - nst009 [pii]
AID - 10.1093/scan/nst009 [doi]
PST - ppublish
SO  - Soc Cogn Affect Neurosci. 2014 Apr;9(4):487-93. doi: 10.1093/scan/nst009. Epub 
      2013 Jan 17.