PMID- 23328497
OWN - NLM
STAT- MEDLINE
DCOM- 20130730
LR  - 20130208
IS  - 1952-4005 (Electronic)
IS  - 1148-5493 (Linking)
VI  - 23
IP  - 4
DP  - 2012 Oct-Dec
TI  - TNF-alpha single nucleotide polymorphisms in atopic dermatitis.
PG  - 163-5
LID - 10.1684/ecn.2012.0323 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) could be considered as potential biomarkers 
      in atopic dermatitis (AD), while its level could be influenced by cytokine single 
      gene polymorphisms (SNP). This study was performed in 89 pediatric patients with 
      AD and 137 controls to assess polymorphisms of the TNF-alpha gene at positions -308 
      and -238, using the polymerase chain reaction and the sequence-specific primers 
      method. The highest positive allelic association that made the patients 
      susceptible to AD was seen for TNF-alpha -238/G (p<0.001) and TNF-alpha -308/G 
      (p = 0.003). The GG genotypes at TNF-alpha -238 and TNF-alpha -308, were both 
      significantly higher in the patients with AD, compared to the controls (p<0.01). 
      The GG haplotype at TNF-alpha (-308,-238) was seen in 92.7% of the patients, which 
      was significantly higher than the controls (p<0.001), while a negative haplotypic 
      association with AD was seen for TNF-alpha (-308, -238) AG and GA (p<0.01). This 
      study showed that the AG genotype of TNF-alpha -308, associated with a high 
      production of cytokines, was significantly decreased in patients with AD, while 
      the low-producing GG genotype, which could lead to low production of TNF-alpha, was 
      over-expressed in the atopic patients.
FAU - Behniafard, Nasrin
AU  - Behniafard N
AD  - Pediatrics Center of Excellence, Children's Medical Center.
FAU - Gharagozlou, Mohammad
AU  - Gharagozlou M
FAU - Farhadi, Elham
AU  - Farhadi E
FAU - Khaledi, Mojdeh
AU  - Khaledi M
FAU - Sotoudeh, Soheila
AU  - Sotoudeh S
FAU - Darabi, Behzad
AU  - Darabi B
FAU - Fathi, Seid Mohammad
AU  - Fathi SM
FAU - Gholizadeh Moghaddam, Zahra
AU  - Gholizadeh Moghaddam Z
FAU - Mahmoudi, Mahdi
AU  - Mahmoudi M
FAU - Aghamohammadi, Asghar
AU  - Aghamohammadi A
FAU - Amirzargar, Ali Akbar
AU  - Amirzargar AA
FAU - Rezaei, Nima
AU  - Rezaei N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur Cytokine Netw
JT  - European cytokine network
JID - 9100879
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Dermatitis, Atopic/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes/genetics
MH  - Humans
MH  - Iran
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2013/01/19 06:00
MHDA- 2013/07/31 06:00
CRDT- 2013/01/19 06:00
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2013/07/31 06:00 [medline]
AID - ecn.2012.0323 [pii]
AID - 10.1684/ecn.2012.0323 [doi]
PST - ppublish
SO  - Eur Cytokine Netw. 2012 Oct-Dec;23(4):163-5. doi: 10.1684/ecn.2012.0323.