PMID- 23329095
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20221207
IS  - 2168-619X (Electronic)
IS  - 2168-6181 (Linking)
VI  - 139
IP  - 1
DP  - 2013 Jan
TI  - Clinical manifestations and treatment of idiopathic and Wegener 
      granulomatosis-associated subglottic stenosis.
PG  - 76-81
LID - 10.1001/jamaoto.2013.1135 [doi]
AB  - OBJECTIVE: To compare and contrast the manifestations and surgical management of 
      subglottic stenosis in patients with airway obstruction attributed to 
      granulomatosis with polyangiitis (GPA), previously known as Wegener 
      granulomatosis, and those with idiopathic subglottic stenosis (iSGS). DESIGN: 
      Retrospective medical chart review. Review of subglottic stenosis cases seen in 
      the otolaryngology department of an academic medical center from 2005 through 
      2010. Data were obtained on disease presentation, operative management. and 
      findings. SETTING: Tertiary referral center. PARTICIPANTS: A total of 24 patients 
      with iSGS and 15 patients with GPA-associated subglottic stenosis (GPA-SGS). 
      RESULTS: All individuals with iSGS were female, and 40% of patients with GPA-SGS 
      were male (P < .01). Patients with iSGS tended to have a higher Myer-Cotton 
      stenosis grade at the time of dilation than those with GPA-SGS (P = .02). 
      Individuals with GPA-SGS were more likely to undergo tracheotomy as a result of 
      disease-related complications than individuals with iSGS (P < .01). No patients 
      with an open airway reconstruction in the iSGS group required follow-up 
      mechanical dilation. In contrast, all patients with open airway reconstructions 
      in the GPA-SGS group underwent more than 1 subsequent airway dilation (P < .01). 
      CONCLUSIONS: While surgical utilization is the mainstay of treatment in iSGS and 
      GPA-SGS, iSGS occurs almost exclusively in females and presents with a greater 
      degree of stenosis at the time of endoscopic dilation. In contrast, GPA-SGS is 
      associated with greater rates of tracheotomy. Open airway reconstruction may be 
      used in the treatment of iSGS and GPA-SGS but is much more effective in iSGS.
FAU - Taylor, Stanford C
AU  - Taylor SC
AD  - School of Medicine, Oregon Health and Science University, Portland, OR 97239, 
      USA.
FAU - Clayburgh, Daniel R
AU  - Clayburgh DR
FAU - Rosenbaum, James T
AU  - Rosenbaum JT
FAU - Schindler, Joshua S
AU  - Schindler JS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - JAMA Otolaryngol Head Neck Surg
JT  - JAMA otolaryngology-- head & neck surgery
JID - 101589542
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Chi-Square Distribution
MH  - Comorbidity
MH  - Endoscopy/methods
MH  - Female
MH  - Granulomatosis with Polyangiitis/*complications
MH  - Humans
MH  - Immunosuppressive Agents/therapeutic use
MH  - Laryngoscopy
MH  - Laryngostenosis/*etiology/*surgery
MH  - Male
MH  - Oregon
MH  - Plastic Surgery Procedures
MH  - Retrospective Studies
MH  - Statistics, Nonparametric
MH  - Tracheotomy
MH  - Treatment Outcome
EDAT- 2013/01/19 06:00
MHDA- 2013/03/13 06:00
CRDT- 2013/01/19 06:00
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 1558018 [pii]
AID - 10.1001/jamaoto.2013.1135 [doi]
PST - ppublish
SO  - JAMA Otolaryngol Head Neck Surg. 2013 Jan;139(1):76-81. doi: 
      10.1001/jamaoto.2013.1135.