PMID- 23329521
OWN - NLM
STAT- MEDLINE
DCOM- 20130614
LR  - 20130118
IS  - 1128-3602 (Print)
IS  - 1128-3602 (Linking)
VI  - 17
IP  - 1
DP  - 2013 Jan
TI  - Pneumonectomy with and without induction chemo-radiotherapy for non-small cell 
      lung cancer: short and long-term results from a single centre.
PG  - 29-40
LID - 1094 [pii]
AB  - BACKGROUND AND OBJECTIVES:   Pneumonectomy for non small cell lung cancer (NSCLC) 
      after induction radio-chemotherapy (IT) has been associated with high 
      peri-operative risk and its safety and efficacy is still debated. The aim of this 
      retrospective study was to compare short and long-term results of pneumonectomy 
      in patients treated with and without IT (radiotherapy plus chemotherapy) for 
      NSCLC. MATERIALS AND METHODS: From 1995 to 2008, 85 consecutive patients 
      underwent pneumonectomy: 49 received pre-operative radiotherapy and chemotherapy 
      (IT group), and 36 patients did not (non-IT group). Peri-operative and long-term 
      outcomes were compared. RESULTS: Major complications rate was 14.3% for IT group 
      and 16.7% for non-IT group (p = n.s.). Mortality rate was 2% in IT group and 5.5% 
      in non-IT group (p = n.s.). Post-operative hospital stay was significantly longer 
      in the IT group (p < 0.0001) as the need for blood transfusion (p = 0.002). 
      Indeed, the mortality rate was similar in the left- and right-sided operations. 5 
      years survival was 45.3% for IT group and 38.4% for non-IT group (p = n.s.) and 5 
      year disease free survival rates were 42.3% vs. 37.8% for the two groups, 
      respectively (p = n.s.). Among the clinical, surgical and pathological features 
      no differences on long term outcomes were found with regards to IT. DISCUSSION: 
      Pneumonectomy is a feasible and safe procedure even after pre-operative IT. Our 
      results showed a prolonged hospitalization and the need for blood transfusion in 
      the IT group.
FAU - Margaritora, S
AU  - Margaritora S
AD  - Division of General Thoracic Surgery, School of Medicine, Catholic University of 
      the Sacred Heart, Rome, Italy.
FAU - Cesario, A
AU  - Cesario A
FAU - Cusumano, G
AU  - Cusumano G
FAU - Dall'armi, V
AU  - Dall'armi V
FAU - Porziella, V
AU  - Porziella V
FAU - Meacci, E
AU  - Meacci E
FAU - Lococo, F
AU  - Lococo F
FAU - D'Angelillo, R
AU  - D'Angelillo R
FAU - Congedo, M T
AU  - Congedo MT
FAU - Granone, P
AU  - Granone P
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
SB  - IM
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/mortality/*therapy
MH  - *Chemoradiotherapy
MH  - Female
MH  - Humans
MH  - Length of Stay
MH  - Lung Neoplasms/mortality/*therapy
MH  - Male
MH  - Middle Aged
MH  - *Pneumonectomy
MH  - Retrospective Studies
EDAT- 2013/01/19 06:00
MHDA- 2013/06/15 06:00
CRDT- 2013/01/19 06:00
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2013/06/15 06:00 [medline]
AID - 1094 [pii]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2013 Jan;17(1):29-40.