PMID- 23329888
OWN - NLM
STAT- MEDLINE
DCOM- 20130712
LR  - 20221207
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 10
IP  - 2
DP  - 2013
TI  - Association between HLA-B*46 allele and Graves disease in Asian populations: a 
      meta-analysis.
PG  - 164-70
LID - 10.7150/ijms.5158 [doi]
AB  - Graves' disease (GD) is a leading cause of hyperthyroidism, which affects 
      1.0-1.6% of the general population. Previous studies reported a higher GD 
      prevalence in Asian populations compared to Caucasian populations. The etiology 
      of GD involves complex interactions between predisposing genes and environmental 
      triggers. Genetic studies have shown that the human leukocyte antigen (HLA) is an 
      important candidate genetic region associated with GD in Asian populations. 
      However, the results were inconsistent and inconclusive. Here, we performed a 
      meta-analysis to evaluate the role of the HLA-B*46 allele in GD in Asian 
      populations. A total of 14 case-controlled studies on the association of the 
      HLA-B*46 allele in 1743 GD patients and 5689 controls were included. Our results 
      showed a trend toward an increased risk of GD in HLA-B*46-positive subjects 
      compared to those HLA-B*46-negative (OR = 2.48; 95% CI = 1.96-3.13, P < 0.01). 
      However, there were some limitations to the current meta-analysis, such as 
      heterogeneity (P(heterogeneity )< 0.01 and I(2 )= 68.0%) or the different typing 
      methods (serological and genotyping methods). The meta-analysis indicated that 
      the HLA-B*46 allele is a risk factor for GD in Asian populations. Future studies 
      on the role of the HLA-B*46 allele in GD should consider complications such as 
      periodic paralysis, ophthalmopathy and recurrence.
FAU - Li, Yiping
AU  - Li Y
AD  - School of Medicine, Yunnan University, Kunming 650091, Yunnan, China.
FAU - Yao, Yufeng
AU  - Yao Y
FAU - Yang, Man
AU  - Yang M
FAU - Shi, Li
AU  - Shi L
FAU - Li, Xianli
AU  - Li X
FAU - Yang, Ying
AU  - Yang Y
FAU - Zhang, Ying
AU  - Zhang Y
FAU - Xiao, Chunjie
AU  - Xiao C
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20130103
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*46:01 antigen)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Genetic Association Studies
MH  - Graves Disease/blood/*genetics/immunology
MH  - HLA-B Antigens/blood/*genetics
MH  - Humans
MH  - Risk Factors
PMC - PMC3547214
OTO - NOTNLM
OT  - Asian populations.
OT  - Graves' disease
OT  - HLA-B*46
OT  - Meta-analysis
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2013/01/19 06:00
MHDA- 2013/07/16 06:00
PMCR- 2013/01/01
CRDT- 2013/01/19 06:00
PHST- 2012/09/03 00:00 [received]
PHST- 2012/12/28 00:00 [accepted]
PHST- 2013/01/19 06:00 [entrez]
PHST- 2013/01/19 06:00 [pubmed]
PHST- 2013/07/16 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - ijmsv10p0164 [pii]
AID - 10.7150/ijms.5158 [doi]
PST - ppublish
SO  - Int J Med Sci. 2013;10(2):164-70. doi: 10.7150/ijms.5158. Epub 2013 Jan 3.