PMID- 23330458
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20130121
IS  - 0301-4894 (Print)
IS  - 0301-4894 (Linking)
VI  - 113
IP  - 6
DP  - 2012 Nov
TI  - [Surgery for pancreatic neuroendocrine tumors].
PG  - 502-6
AB  - Approximately half of pancreatic neuroendocrine tumors (PNETs) are 
      nonfunctioning, and insulinoma and gastrinoma are frequent forms of functioning 
      tumors. The treatment of patients with PNETs should be based on the consideration 
      that more than half are malignant except for insulinomas. Multiple endocrine 
      neoplasia type 1 (MEN1) is often complicated with gastrinoma. Endoscopic 
      ultrasound and somatostain receptor scintigraphy are useful in diagnosing PNETs, 
      and the selective arterial secretagogue injection test is performed if necessary. 
      WHO2010 is available as a histopathologic grading system of malignancy. Although 
      surgical resection should first be considered as a treatment for PNETs, liver 
      metastasis is a major factor hindering resection. In Japan, the choices of drugs 
      to treat liver metastases are too few. In patients with MEN1 in whom PNETS are 
      frequently multiple, we should perform procedures that preserve pancreatic 
      function, although some patients may require total pancreatectomy for the 
      complete resection of tumors. The indications for total pancreatectomy should be 
      determined individually based on the tumor status and patient age.
FAU - Shibata, Chikashi
AU  - Shibata C
AD  - Division of Biological Regulation and Oncology, Tohoku University School of 
      Medicine, Sendai, Japan.
FAU - Egawa, Shin-Ichi
AU  - Egawa S
FAU - Motoi, Fuyuhiko
AU  - Motoi F
FAU - Morikawa, Takanori
AU  - Morikawa T
FAU - Naitoh, Takeshi
AU  - Naitoh T
FAU - Unno, Michiaki
AU  - Unno M
FAU - Sasaki, Iwao
AU  - Sasaki I
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Geka Gakkai Zasshi
JT  - Nihon Geka Gakkai zasshi
JID - 0405405
SB  - IM
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/complications
MH  - Neuroendocrine Tumors/diagnosis/pathology/*surgery
MH  - Pancreatectomy
MH  - Pancreatic Neoplasms/diagnosis/pathology/*surgery
EDAT- 2013/01/22 06:00
MHDA- 2013/04/10 06:00
CRDT- 2013/01/22 06:00
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
PST - ppublish
SO  - Nihon Geka Gakkai Zasshi. 2012 Nov;113(6):502-6.