PMID- 23330836
OWN - NLM
STAT- MEDLINE
DCOM- 20140211
LR  - 20221207
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 40
IP  - 4
DP  - 2013 Apr
TI  - Association of human leukocyte antigen class I antigens in Iranian patients with 
      pemphigus vulgaris.
PG  - 244-8
LID - 10.1111/1346-8138.12071 [doi]
AB  - There are a limited number of reports indicating the role of human leukocyte 
      antigen (HLA) class I alleles in pemphigus vulgaris. This study was designed to 
      highlight the association of HLA class I alleles with pemphigus vulgaris in Iran. 
      Fifty patients with pemphigus vulgaris, diagnosed based on clinical, histological 
      and direct immunofluorescence findings were enrolled into this study. The control 
      group consisted of 50 healthy, age- and sex-matched individuals. HLA typing of 
      class I (A, B and C alleles) was carried out using polymerase chain reaction 
      based on the sequence-specific primer method. This study showed the higher 
      frequency of HLA-B*44:02 (P = 0.007), -C*04:01 (P < 0.001), -C*15:02 (P < 0.001) 
      and -C*16:01 (P = 0.027) in the patient group, compared to the controls, while 
      the frequency of HLA-C*06:02 (P < 0.001) and -C*18:01 (P = 0.008) in the patients 
      with pemphigus vulgaris was significantly lower than the controls. Regarding the 
      linkage disequilibrium between HLA class I alleles, the HLA-A*03:01, -B*51:01, 
      -C*16:02 haplotype (4% vs 0%, P = 0.04) is suggested to be a predisposing factor, 
      whereas HLA-A*26:01, -B*38, -C*12:03 haplotype (0% vs 6%, P = 0.01) is suggested 
      to be a protective factor. In conclusion, it is suggested that HLA-B*44:02, 
      -C*04:01, -C*15:02 alleles and HLA-A*03:01, -B*51:01, -C*16:02 haplotype are 
      susceptibility factors for development of pemphigus vulgaris in the Iranian 
      population, while HLA-C*06:02, -C*18:01 alleles and HLA-A*26:01, -B*38, -C*12:03 
      haplotype may be considered as protective alleles.
CI  - (c) 2013 Japanese Dermatological Association.
FAU - Mortazavi, Hossein
AU  - Mortazavi H
AD  - Autoimmune Bullous Diseases Research Center, Department of Dermatology, Razi 
      Hospital, Tehran, Iran. mortazavikerman@gmail.com
FAU - Amirzargar, Ali Akbar
AU  - Amirzargar AA
FAU - Esmaili, Nafiseh
AU  - Esmaili N
FAU - Toofan, Hesam
AU  - Toofan H
FAU - Ehsani, Amir Hooshang
AU  - Ehsani AH
FAU - Hosseini, Seyed Hamed
AU  - Hosseini SH
FAU - Rezaei, Nima
AU  - Rezaei N
LA  - eng
PT  - Journal Article
DEP - 20130121
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/genetics
MH  - Haplotypes/genetics
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Iran
MH  - Jews/genetics
MH  - Leukocytes/immunology
MH  - Male
MH  - Pemphigus/*genetics/immunology
MH  - Polymerase Chain Reaction
MH  - White People/genetics
EDAT- 2013/01/22 06:00
MHDA- 2014/02/12 06:00
CRDT- 2013/01/22 06:00
PHST- 2012/01/27 00:00 [received]
PHST- 2012/11/19 00:00 [accepted]
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2014/02/12 06:00 [medline]
AID - 10.1111/1346-8138.12071 [doi]
PST - ppublish
SO  - J Dermatol. 2013 Apr;40(4):244-8. doi: 10.1111/1346-8138.12071. Epub 2013 Jan 21.