PMID- 23330953
OWN - NLM
STAT- MEDLINE
DCOM- 20130626
LR  - 20240503
IS  - 1545-3278 (Electronic)
IS  - 0732-0582 (Print)
IS  - 0732-0582 (Linking)
VI  - 31
DP  - 2013
TI  - Molecular control of steady-state dendritic cell maturation and immune 
      homeostasis.
PG  - 743-91
LID - 10.1146/annurev-immunol-020711-074929 [doi]
AB  - Dendritic cells (DCs) are specialized sentinels responsible for coordinating 
      adaptive immunity. This function is dependent upon coupled sensitivity to 
      environmental signs of inflammation and infection to cellular maturation-the 
      programmed alteration of DC phenotype and function to enhance immune cell 
      activation. Although DCs are thus well equipped to respond to pathogens, 
      maturation triggers are not unique to infection. Given that immune cells are 
      exquisitely sensitive to the biological functions of DCs, we now appreciate that 
      multiple layers of suppression are required to restrict the environmental 
      sensitivity, cellular maturation, and even life span of DCs to prevent aberrant 
      immune activation during the steady state. At the same time, steady-state DCs are 
      not quiescent but rather perform key functions that support homeostasis of 
      numerous cell types. Here we review these functions and molecular mechanisms of 
      suppression that control steady-state DC maturation. Corruption of these 
      steady-state operatives has diverse immunological consequences and pinpoints DCs 
      as potent drivers of autoimmune and inflammatory disease.
FAU - Hammer, Gianna Elena
AU  - Hammer GE
AD  - Department of Medicine, University of California, San Francisco, California 
      94143, USA. Gianna.Hammer@ucsf.edu
FAU - Ma, Averil
AU  - Ma A
LA  - eng
GR  - R01 DK095693/DK/NIDDK NIH HHS/United States
GR  - P30 DK026743/DK/NIDDK NIH HHS/United States
GR  - R01 DK071939/DK/NIDDK NIH HHS/United States
GR  - T32 DK007007/DK/NIDDK NIH HHS/United States
GR  - P01 AI078869/AI/NIAID NIH HHS/United States
GR  - P30 DK042086/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20130117
PL  - United States
TA  - Annu Rev Immunol
JT  - Annual review of immunology
JID - 8309206
RN  - 0 (CLEC4A protein, human)
RN  - 0 (Dcir protein, mouse)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Pattern Recognition)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/genetics/*immunology
MH  - Dendritic Cells/*cytology/*immunology/metabolism
MH  - Homeostasis/genetics/*immunology
MH  - Humans
MH  - Lectins, C-Type/physiology
MH  - Membrane Glycoproteins/physiology
MH  - Mice
MH  - Receptors, Immunologic/physiology
MH  - Receptors, Pattern Recognition/physiology
MH  - Signal Transduction/genetics/*immunology
MH  - Toll-Like Receptors/physiology
PMC - PMC4091962
MID - NIHMS593613
EDAT- 2013/01/22 06:00
MHDA- 2013/06/28 06:00
PMCR- 2014/07/10
CRDT- 2013/01/22 06:00
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/06/28 06:00 [medline]
PHST- 2014/07/10 00:00 [pmc-release]
AID - 10.1146/annurev-immunol-020711-074929 [doi]
PST - ppublish
SO  - Annu Rev Immunol. 2013;31:743-91. doi: 10.1146/annurev-immunol-020711-074929. 
      Epub 2013 Jan 17.