PMID- 23331362
OWN - NLM
STAT- MEDLINE
DCOM- 20130618
LR  - 20220330
IS  - 1753-6405 (Electronic)
IS  - 1326-0200 (Linking)
VI  - 34
IP  - 2
DP  - 2010 Apr
TI  - Lifestyle and medication interventions for the prevention or delay of type 2 
      diabetes mellitus in prediabetes: a systematic review of randomised controlled 
      trials.
PG  - 172-8
LID - 10.1111/j.1753-6405.2010.00503.x [doi]
AB  - OBJECTIVE: To assess lifestyle and pharmacological interventions aiming to delay 
      type 2 diabetes mellitus (T2DM) in prediabetes. METHODS: We searched the Cochrane 
      Register of Controlled Trials, MEDLINE, EMBASE, CINAHL, PsycINFO, Web of Science, 
      BIOSIS and LILACS databases, examined reference lists and contacted authors. We 
      included randomised controlled trials (RCTs) on both lifestyle and medication 
      interventions in prediabetes. These studies were at least 12 month duration and 
      aimed to delay T2DM. RESULTS: Four studies investigating lifestyle and medication 
      with a total of 5,196 participants were identified. There was a high risk of bias 
      in the studies and the interventions utilised varied considerably; thus, 
      meta-analysis was not undertaken. The comparison between lifestyle and medication 
      interventions was largely dependent on the intensity of the lifestyle program 
      while we could not adequately assess their effects on cardiovascular morbidity. 
      Adverse events with metformin and acarbose were common. CONCLUSION: There is 
      substantial evidence that intensive lifestyle programs and medications delay T2DM 
      in impaired glucose tolerance though it remains unclear which is more effective. 
      IMPLICATIONS: Both interventions seem to be able to delay T2DM. However, both 
      have issues with adherence and side effects and more RCTs are required.
CI  - (c) 2010 The Authors. Journal Compilation (c) 2010 Public Health Association of 
      Australia.
FAU - Yuen, Agnes
AU  - Yuen A
AD  - Emergency Practice Innovation Centre, St Vincent's Hospital Melbourne and Faculty 
      of Medicine, Dentistry and Health Sciences, The University of Melbourne, 
      Victoria, Australia.
FAU - Sugeng, Yulia
AU  - Sugeng Y
FAU - Weiland, Tracey J
AU  - Weiland TJ
FAU - Jelinek, George A
AU  - Jelinek GA
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - Aust N Z J Public Health
JT  - Australian and New Zealand journal of public health
JID - 9611095
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*prevention & control
MH  - Female
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - *Life Style
MH  - Male
MH  - Prediabetic State/*therapy
MH  - Publication Bias
MH  - *Randomized Controlled Trials as Topic
MH  - Treatment Outcome
EDAT- 2010/04/01 00:00
MHDA- 2013/06/19 06:00
CRDT- 2013/01/22 06:00
PHST- 2013/01/22 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1111/j.1753-6405.2010.00503.x [doi]
PST - ppublish
SO  - Aust N Z J Public Health. 2010 Apr;34(2):172-8. doi: 
      10.1111/j.1753-6405.2010.00503.x.