PMID- 23331488
OWN - NLM
STAT- MEDLINE
DCOM- 20130827
LR  - 20230815
IS  - 1474-9726 (Electronic)
IS  - 1474-9718 (Linking)
VI  - 12
IP  - 2
DP  - 2013 Apr
TI  - Autophagy mediates caloric restriction-induced lifespan extension in Arabidopsis.
PG  - 327-9
LID - 10.1111/acel.12048 [doi]
AB  - Caloric restriction (CR) extends lifespan in various heterotrophic organisms 
      ranging from yeasts to mammals, but whether a similar phenomenon occurs in plants 
      remains unknown. Plants are autotrophs and use their photosynthetic machinery to 
      convert light energy into the chemical energy of glucose and other organic 
      compounds. As the rate of photosynthesis is proportional to the level of 
      photosynthetically active radiation, the CR in plants can be modeled by lowering 
      light intensity. Here, we report that low light intensity extends the lifespan in 
      Arabidopsis through the mechanisms triggering autophagy, the major catabolic 
      process that recycles damaged and potentially harmful cellular material. Knockout 
      of autophagy-related genes results in the short lifespan and suppression of the 
      lifespan-extending effect of the CR. Our data demonstrate that the 
      autophagy-dependent mechanism of CR-induced lifespan extension is conserved 
      between autotrophs and heterotrophs.
CI  - (c) 2013 The Authors Aging Cell (c) 2013 Blackwell Publishing Ltd/Anatomical Society 
      of Great Britain and Ireland.
FAU - Minina, Elena A
AU  - Minina EA
AD  - Department of Plant Biology and Forest Genetics, Uppsala BioCenter, Swedish 
      University of Agricultural Sciences and Linnean Center for Plant Biology, PO Box 
      7080, Uppsala, SE-75007, Sweden.
FAU - Sanchez-Vera, Victoria
AU  - Sanchez-Vera V
FAU - Moschou, Panagiotis N
AU  - Moschou PN
FAU - Suarez, Maria F
AU  - Suarez MF
FAU - Sundberg, Eva
AU  - Sundberg E
FAU - Weih, Martin
AU  - Weih M
FAU - Bozhkov, Peter V
AU  - Bozhkov PV
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130228
PL  - England
TA  - Aging Cell
JT  - Aging cell
JID - 101130839
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (Autophagy-Related Protein 5)
RN  - EC 3.1.3.- (Atg5 protein, Arabidopsis)
RN  - EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Arabidopsis/*genetics/metabolism/radiation effects
MH  - Arabidopsis Proteins/genetics
MH  - Autophagy/*genetics/radiation effects
MH  - Autophagy-Related Protein 5
MH  - Caloric Restriction
MH  - Glucose/metabolism
MH  - Light
MH  - Longevity/genetics/radiation effects
MH  - Phosphoric Monoester Hydrolases/deficiency/genetics
MH  - Photosynthesis/physiology
MH  - *Plants, Genetically Modified
EDAT- 2013/01/22 06:00
MHDA- 2013/08/28 06:00
CRDT- 2013/01/22 06:00
PHST- 2013/01/08 00:00 [accepted]
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/08/28 06:00 [medline]
AID - 10.1111/acel.12048 [doi]
PST - ppublish
SO  - Aging Cell. 2013 Apr;12(2):327-9. doi: 10.1111/acel.12048. Epub 2013 Feb 28.