PMID- 23331675
OWN - NLM
STAT- MEDLINE
DCOM- 20130703
LR  - 20130121
IS  - 1365-3164 (Electronic)
IS  - 0959-4493 (Linking)
VI  - 24
IP  - 1
DP  - 2013 Feb
TI  - Serum anti-Staphylococcus pseudintermedius IgE and IgG antibodies in dogs with 
      atopic dermatitis and nonatopic dogs.
PG  - 19-24.e5-6
LID - 10.1111/j.1365-3164.2012.01109.x [doi]
AB  - BACKGROUND: Dogs and humans with atopic dermatitis (AD) are predisposed to 
      colonization and recurrent infection with Staphylococcus spp. Studies in humans 
      suggest that staphylococcus-specific immunoglobulin E (IgE) plays a key role in 
      disease pathogenesis. Few such studies have been undertaken in dogs. 
      HYPOTHESIS/OBJECTIVES: The aim of this study was to compare levels of 
      staphylococcus-specific IgE and immunoglobulin G (IgG) in dogs with AD, nonatopic 
      dogs with staphylococcal pyoderma, and nonatopic and noninfected control dogs. 
      ANIMALS: Sera were collected from 108 dogs with AD, 39 nonatopic dogs with 
      staphylococcal pyoderma secondary to different underlying conditions, 67 
      age-matched nonatopic control dogs, and nine control dogs reared in minimal 
      disease conditions. METHODS: Serum Staphylococcus pseudintermedius-specific IgE 
      and IgG antibodies were measured by enzyme-linked immunosorbent assay. RESULTS: 
      Dogs with AD had significantly higher levels of anti-staphylococcal IgE than 
      nonatopic dogs with staphylococcal pyoderma and the two groups of control dogs. 
      Levels of anti-staphylococcal IgG were significantly higher in atopic dogs and 
      nonatopic dogs with pyoderma compared with nonatopic control dogs and control 
      dogs reared in minimal disease conditions, but there was no significant 
      difference in levels of anti-staphylococcal IgG between dogs with AD and 
      nonatopic dogs with pyoderma. CONCLUSIONS AND CLINICAL IMPORTANCE: A 
      significantly increased IgE response to S. pseudintermedius antigens in atopic 
      dogs suggests an immunopathogenic role for anti-staphylococcal IgE. The finding 
      of elevated IgE and IgG in atopic dogs is also important as a prelude to studies 
      on antigenic specificity and possible correlations with disease phenotype.
CI  - (c) 2013 The Authors. Veterinary Dermatology (c) 2013 ESVD and ACVD.
FAU - Bexley, Jennifer
AU  - Bexley J
AD  - Avacta Animal Health, Unit 651, Street 5, Thorp Arch Estate, Wetherby, Leeds LS23 
      7FZ, UK. jennifer.bexley@avacta.com
FAU - Nuttall, Timothy J
AU  - Nuttall TJ
FAU - Hammerberg, Bruce
AU  - Hammerberg B
FAU - Fitzgerald, J Ross
AU  - Fitzgerald JR
FAU - Halliwell, Richard E
AU  - Halliwell RE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Vet Dermatol
JT  - Veterinary dermatology
JID - 9426187
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Immunoglobulin G)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antibodies, Bacterial/*blood
MH  - Case-Control Studies
MH  - Dermatitis, Atopic/blood/*veterinary
MH  - Dog Diseases/*blood
MH  - Dogs
MH  - Enzyme-Linked Immunosorbent Assay/veterinary
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulin G/*blood
MH  - Staphylococcus/*immunology
EDAT- 2013/01/22 06:00
MHDA- 2013/07/05 06:00
CRDT- 2013/01/22 06:00
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/07/05 06:00 [medline]
AID - 10.1111/j.1365-3164.2012.01109.x [doi]
PST - ppublish
SO  - Vet Dermatol. 2013 Feb;24(1):19-24.e5-6. doi: 10.1111/j.1365-3164.2012.01109.x.