PMID- 23333344
OWN - NLM
STAT- MEDLINE
DCOM- 20130731
LR  - 20211021
IS  - 1878-108X (Electronic)
IS  - 0166-2236 (Print)
IS  - 0166-2236 (Linking)
VI  - 36
IP  - 2
DP  - 2013 Feb
TI  - BDNF and the central control of feeding: accidental bystander or essential 
      player?
PG  - 83-90
LID - S0166-2236(12)00225-1 [pii]
LID - 10.1016/j.tins.2012.12.009 [doi]
AB  - A considerable body of evidence links diminished brain-derived neurotrophic 
      factor (BDNF) signaling to energy balance dysregulation and severe obesity in 
      humans and rodents. Because BDNF exhibits broad neurotrophic properties, the 
      underpinnings of these effects and its true role in the central regulation of 
      food intake remain topics of debate in the field. Here, I discuss recent evidence 
      supporting a critical role for this neurotrophin in physiological mechanisms 
      regulating nutrient intake and body weight in the mature brain. They include 
      reports of functional interactions of BDNF with central anorexigenic and 
      orexigenic signaling pathways and evidence of recognized appetite hormones 
      exerting neurotrophic effects similar to those of BDNF.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Rios, Maribel
AU  - Rios M
AD  - Tufts University School of Medicine, Department of Neuroscience, Boston, MA 
      02111, USA. maribel.rios@tufts.edu
LA  - eng
GR  - R01 DK073311/DK/NIDDK NIH HHS/United States
GR  - DK073311/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20130118
PL  - England
TA  - Trends Neurosci
JT  - Trends in neurosciences
JID - 7808616
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Brain/*physiology
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Eating/*physiology
MH  - Feeding Behavior/*physiology
MH  - Humans
PMC - PMC3568936
MID - NIHMS438803
EDAT- 2013/01/22 06:00
MHDA- 2013/08/01 06:00
PMCR- 2014/02/01
CRDT- 2013/01/22 06:00
PHST- 2012/10/26 00:00 [received]
PHST- 2012/12/19 00:00 [revised]
PHST- 2012/12/20 00:00 [accepted]
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/08/01 06:00 [medline]
PHST- 2014/02/01 00:00 [pmc-release]
AID - S0166-2236(12)00225-1 [pii]
AID - 10.1016/j.tins.2012.12.009 [doi]
PST - ppublish
SO  - Trends Neurosci. 2013 Feb;36(2):83-90. doi: 10.1016/j.tins.2012.12.009. Epub 2013 
      Jan 18.