PMID- 23333513
OWN - NLM
STAT- MEDLINE
DCOM- 20130808
LR  - 20211021
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Print)
IS  - 0048-9697 (Linking)
VI  - 445-446
DP  - 2013 Feb 15
TI  - Associations between brominated flame retardants in house dust and hormone levels 
      in men.
PG  - 177-84
LID - S0048-9697(12)01560-4 [pii]
LID - 10.1016/j.scitotenv.2012.12.017 [doi]
AB  - Brominated flame retardants (BFRs) are used in the manufacture of a variety of 
      materials and consumer products in order to meet fire safety standards. BFRs may 
      persist in the environment and have been detected in wildlife, humans and indoor 
      dust and air. Some BFRs have demonstrated endocrine and reproductive effects in 
      animals, but human studies are limited. In this exploratory study, we measured 
      serum hormone levels and flame retardant concentrations [31 polybrominated 
      diphenyl ether (PBDE) congeners and 6 alternate flame retardants] in house dust 
      from men recruited through a US infertility clinic. PBDE congeners in dust were 
      grouped by commercial mixtures (i.e. penta-, octa- and deca-BDE). In 
      multivariable linear regression models adjusted by age and body mass index (BMI), 
      significant positive associations were found between house dust concentrations of 
      pentaBDEs and serum levels of free T4, total T3, estradiol, and sex hormone 
      binding globulin (SHBG), along with an inverse association with follicle 
      stimulating hormone (FSH). There were also positive associations of octaBDE 
      concentrations with serum free T4, thyroid stimulating hormone (TSH), luteinizing 
      hormone (LH) and testosterone and an inverse association of decaBDE 
      concentrations with testosterone. Hexabromocyclododecane (HBCD) was associated 
      with decreased SHBG and increased free androgen index. Dust concentrations of 
      bis-tribromophenoxyethane (BTBPE) and tetrabromo-diethylhexylphthalate (TBPH) 
      were positively associated with total T3. These findings are consistent with our 
      previous report of associations between PBDEs (BDE 47, 99 and 100) in house dust 
      and hormone levels in men, and further suggest that exposure to contaminants in 
      indoor dust may be leading to endocrine disruption in men.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Johnson, Paula I
AU  - Johnson PI
AD  - Department of Environmental Health Sciences, University of Michigan, 1415 
      Washington Heights, Ann Arbor, MI 48109, USA.
FAU - Stapleton, Heather M
AU  - Stapleton HM
FAU - Mukherjee, Bhramar
AU  - Mukherjee B
FAU - Hauser, Russ
AU  - Hauser R
FAU - Meeker, John D
AU  - Meeker JD
LA  - eng
GR  - P30 ES017885/ES/NIEHS NIH HHS/United States
GR  - R01 ES009718/ES/NIEHS NIH HHS/United States
GR  - R01 ES016099/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130116
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Dust)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Flame Retardants)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 3XMK78S47O (Testosterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Dust
MH  - Endocrine Disruptors/analysis/toxicity
MH  - Environmental Pollutants/*analysis/toxicity
MH  - Estradiol/blood
MH  - Flame Retardants/*analysis/toxicity
MH  - Gonadal Steroid Hormones/*blood
MH  - Halogenated Diphenyl Ethers/analysis/toxicity
MH  - Humans
MH  - Infertility, Male
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Sex Hormone-Binding Globulin/*metabolism
MH  - Testosterone/blood
PMC - PMC3572297
MID - NIHMS436838
EDAT- 2013/01/22 06:00
MHDA- 2013/08/09 06:00
PMCR- 2014/02/15
CRDT- 2013/01/22 06:00
PHST- 2012/07/02 00:00 [received]
PHST- 2012/12/06 00:00 [revised]
PHST- 2012/12/06 00:00 [accepted]
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/08/09 06:00 [medline]
PHST- 2014/02/15 00:00 [pmc-release]
AID - S0048-9697(12)01560-4 [pii]
AID - 10.1016/j.scitotenv.2012.12.017 [doi]
PST - ppublish
SO  - Sci Total Environ. 2013 Feb 15;445-446:177-84. doi: 
      10.1016/j.scitotenv.2012.12.017. Epub 2013 Jan 16.